Related Experiment Video
Updated: Jun 9, 2026
14:25
Assessment of Ovarian Cancer Spheroid Attachment and Invasion of Mesothelial Cells in Real Time
Published on: May 20, 2014
17.4K
Redefining the standard of care for low-grade serous ovarian cancer
Beryl L Manning-Geist1, Tal Cantor2, Róisín E O'Cearbhaill3,4
1Gynecology Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, New York.
Clinical Advances in Hematology & Oncology : H&O
|May 28, 2024
Summary
Low-grade serous carcinoma, a rare ovarian cancer, is benefiting from new research. Treatment is shifting away from high-grade paradigms towards targeted therapies and hormonal options for better patient outcomes.
Area of Science:
- Gynecologic Oncology
- Cancer Biology
- Translational Medicine
Background:
- Low-grade serous carcinoma (LGSC) is a rare epithelial ovarian cancer subtype.
- LGSC exhibits distinct clinical, histologic, and molecular characteristics.
- Traditional treatment has followed high-grade serous carcinoma (HGSC) protocols.
Purpose of the Study:
- To review recent advances in understanding and treating LGSC.
- To highlight emerging therapeutic strategies tailored to LGSC.
- To emphasize the need for LGSC-specific treatment paradigms.
Main Methods:
- Review of current literature and clinical trial data.
- Analysis of molecular pathways implicated in LGSC.
- Evaluation of novel therapeutic targets and treatment approaches.
Main Results:
- New data challenge the efficacy of platinum retreatment in LGSC.
- First-line hormonal therapy is a viable option for LGSC.
- Targeted therapies for MAPK and cyclin D kinase pathways show promise.
Conclusions:
- LGSC requires distinct treatment strategies, separate from HGSC.
- Hormonal and targeted therapies represent significant advances for LGSC.
- Further research is crucial to optimize LGSC management.
Related Concept Videos
02:56Treatment Resistant Cancers
Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...
02:56Treatment Resistent Cancers
Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...
01:22Standards of Care I
Federal statutes profoundly impact nursing practice, providing critical guidelines to ensure patient care is equitable, accessible, and of the highest quality. The following laws address distinct aspects of healthcare provision and patient rights:
01:19Standards of Care II
Nurses bear specific legal responsibilities under several federal statutes, including: