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Related Experiment Video

Updated: Jun 25, 2025

Electroacupuncture Combined with Chinese Medicine Ironing Therapy for Functional Constipation
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Identifying the association between depression and constipation: An observational study and Mendelian randomization

Shasha Wu1, Guojun Yuan1, Linlin Wu2

  • 1Department of Gastroenterology, The Third Hospital of Mianyang, Sichuan Mental Health Center, Mianyang, Sichuan, PR China.

Journal of Affective Disorders
|May 28, 2024
PubMed
Summary

Depression significantly increases the risk of constipation, with a clear causal link found. This highlights the need for clinicians to consider constipation when managing depression patients.

Keywords:
AssociationConstipationDepressionMendelian randomizationNHANES

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Area of Science:

  • Medical research
  • Genetics
  • Psychiatry

Background:

  • Depression and constipation are prevalent disorders impacting quality of life.
  • The precise relationship and causality between these conditions remain unclear.

Purpose of the Study:

  • To investigate the phenotypic relationship and causality between depression and constipation.
  • To assess the influence of depression severity on this relationship.

Main Methods:

  • Logistic regression analysis on large-scale survey data (N=11,585).
  • Bidirectional two-sample Mendelian randomization (MR) using Genome-wide association study (GWAS) data for depression (N=807,553) and constipation (N=377,277).
  • Further MR analysis on major depression GWAS data (N=480,359) to evaluate depression severity impact.

Main Results:

  • A significant positive correlation was observed between depression and constipation (OR=1.968).
  • Depression was found to have a causal effect on constipation, but not vice versa.
  • Severe depression was associated with a higher risk of constipation compared to mild depression.

Conclusions:

  • Depression is causally linked to an increased risk of constipation.
  • Clinicians should be vigilant about the risk of constipation in patients with depression.