Related Experiment Video
Updated: Jun 25, 2025
07:40
Experimental Autoimmune Uveitis: An Intraocular Inflammatory Mouse Model
Published on: January 12, 2022
4.8K
Approach to Immune-mediated Ocular Diseases.
Kelly E Knickelbein1, Mary E Lassaline2
1Department of Clinical Sciences, Cornell University College of Veterinary Medicine, 930 Campus Road, Ithaca, NY 14853, USA.
Summary
Diagnosing immune-mediated keratitis and uveitis in horses involves excluding other causes and observing treatment response. This review covers current approaches to managing these equine eye conditions.
Area of Science:
- Veterinary Ophthalmology
- Equine Internal Medicine
Background:
- Immune-mediated ocular inflammation, including keratitis and uveitis, is a common diagnosis in horses.
- This diagnosis is reached by excluding other potential causes like infections or tumors.
- Treatment response to anti-inflammatory drugs supports the diagnosis but requires caution due to contraindications.
Purpose of the Study:
- To summarize the current understanding of immune-mediated keratitis in horses.
- To outline the diagnostic approach for recurrent or insidious uveitis in horses.
- To review management strategies for immune-mediated ocular conditions in equine patients.
Main Methods:
- Literature review of diagnostic criteria for equine ocular inflammation.
- Analysis of treatment protocols for immune-mediated keratitis and uveitis.
- Discussion of differential diagnoses including infectious and neoplastic causes.
Main Results:
- Diagnosis relies heavily on exclusion and response to therapy.
- Careful differentiation from infectious or neoplastic conditions is critical.
- Management involves targeted anti-inflammatory and immunomodulatory treatments.
Conclusions:
- Accurate diagnosis of immune-mediated ocular disease in horses is challenging.
- Exclusion of other causes and careful monitoring are key.
- Effective management requires a thorough understanding of equine ocular pathology.
Related Concept Videos
01:25Glaucoma: Overview
548
Glaucoma is an eye condition characterized by increased intraocular pressure that damages the retina and optic nerve, leading to irreversible blindness if left untreated. The human eye has various components, including the cornea, iris, pupil, lens, and optic nerve. Aqueous humor is secreted by the epithelium of the ciliary body in the posterior chamber and flows through the trabecular meshwork and canal of Schlemm, maintaining normal intraocular pressure. The trabecular meshwork and the canal...
548
01:27Open Angle Glaucoma: Treatment
430
In open-angle glaucoma, the iridocorneal angle remains open, but the trabecular meshwork becomes stiff, slowing down the outflow of aqueous humor. This causes a buildup of aqueous humor in the anterior chamber, leading to a sudden increase in intraocular pressure. The treatment for open-angle glaucoma focuses on reducing the elevated intraocular pressure by either decreasing the secretion of aqueous humor or increasing its outflow.
Drugs such as carbonic anhydrase inhibitors, α2- and...
Drugs such as carbonic anhydrase inhibitors, α2- and...
430
01:28Angle Closure Glaucoma: Treatment
479
Angle-closure glaucoma, or closed-angle glaucoma, is an eye condition where the iris bulges out and blocks the iridocorneal angle, resulting in a buildup of aqueous humor and increased intraocular pressure. Immediate medical attention is necessary due to the sudden onset of symptoms. The treatment for angle-closure glaucoma includes short-term and long-term approaches. Short-term treatment involves using eye drops like pilocarpine to lower intraocular pressure by increasing aqueous humor...
479
01:17Accessory Structures of the Eye
1.5K
Optical perception, or vision, is an extraordinary sense dependent on converting light signals received via the ocular organs. These organs, known as eyes, are securely positioned within the bony cavities of the skull, called orbits. The orbits serve a dual purpose: a protective shield for the ocular globes and a stable attachment point for the soft ocular tissues. The eye's external protective mechanisms include the eyelids, which are edged with lashes that act as a barrier against foreign...
1.5K