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Related Experiment Videos

Autoimmunity in hereditary retinal degeneration. I. Basic studies.

S M Chant, J Heckenlively, R H Meyers-Elliott

    The British Journal of Ophthalmology
    |January 1, 1985
    PubMed
    Summary

    Autoimmune responses are common in retinitis pigmentosa (RP) and other eye diseases. This study found antibodies and cell-mediated immunity to retinal antigens in many patients, suggesting a potential role in ocular disorders.

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    Area of Science:

    • Ophthalmology
    • Immunology
    • Retinal Diseases

    Background:

    • Retinitis pigmentosa (RP) is a group of inherited retinal diseases.
    • Autoimmune processes are implicated in various degenerative ocular disorders.

    Purpose of the Study:

    • To investigate the presence and extent of antiretinal autoimmune activity in patients with retinitis pigmentosa (RP).
    • To compare autoimmune responses in RP patients with those in patients with other eye diseases and healthy controls.

    Main Methods:

    • Sera from 116 RP patients, 64 patients with other eye diseases, and 36 controls were screened for antibodies to retinal antigens using indirect immunofluorescence.
    • Lymphocyte transformation assays were employed to detect cell-mediated immunity to retinal antigens.

    Main Results:

    • Antibodies reacting with retinal antigens were detected in 37% of RP patients, 33% of non-RP patients, and 2% of controls.
    • Lymphocyte sensitization to retinal antigens was observed in 19% of RP patients, 18% of non-RP patients, and 10% of controls.

    Conclusions:

    • Autoimmune responses, including antibody production and cell-mediated immunity, are prevalent in patients with retinitis pigmentosa and other degenerative eye conditions.
    • The pathogenic role of these autoimmune responses in the progression of ocular disorders remains to be elucidated.

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