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Time of exercise differentially impacts bone growth in mice
Shaoling Yu1,2,3, Qingming Tang1,2,3, Xiaofeng Lu1,2,3
1Department of Stomatology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Nature Metabolism
|May 28, 2024
Summary
Exercising during the early active phase significantly boosts bone growth in mice by regulating bone metabolism and oxidative phosphorylation. This timing optimizes physical activity for enhanced bone development.
Area of Science:
- Exercise physiology
- Bone biology
- Chronobiology
Background:
- Physical training is known to improve bone mass.
- The optimal timing of exercise for bone growth is not well understood.
Purpose of the Study:
- To determine the effect of exercise timing on bone growth.
- To investigate the molecular mechanisms underlying exercise-induced bone growth.
Main Methods:
- Transcriptomic and metabolomic analyses in mice.
- Pharmacological interventions to confirm findings.
- Signaling network construction.
Main Results:
- Exercise during the early active phase significantly increased bone length in male and female mice.
- Early active phase exercise upregulated genes involved in bone development and metabolism.
- Rhythmic expression of oxidative phosphorylation genes in the chondrification center peaked during the early active phase.
Conclusions:
- Exercise timing critically influences bone growth.
- The early active phase is optimal for exercise-induced bone growth.
- Targeting oxidative phosphorylation may enhance bone development interventions.
