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A comprehensive correlation of the KI-67 proliferation index to patient´s, imaging and tumor features and its value in predicting long-term course of patients with newly diagnosed intracranial meningiomas

  • 0Department of Neurosurgery, Helios Clinic Erfurt, Nordhaeuser Str. 74, 99089, Erfurt, Germany.
Neurosurgical Review +

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May 28, 2024

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May 28, 2024

View abstract on PubMed

Summary

This summary is machine-generated.

The KI-67-Proliferation Index (KI-67-PI) correlates with intracranial meningioma (IM) aggressiveness. Higher KI-67-PI indicates increased risk, appearing in males, older patients, larger tumors, and predicting recurrence.

Area Of Science

  • Neurosurgery
  • Oncology
  • Radiology

Background

  • Intracranial meningiomas (IM) are common primary brain tumors.
  • Assessing tumor aggressiveness is crucial for treatment planning and prognosis.
  • The KI-67-Proliferation Index (KI-67-PI) is a marker of cellular proliferation.

Purpose Of The Study

  • To investigate the correlation of KI-67-PI with patient demographics, preoperative MRI characteristics, WHO grading, histological subtype, and long-term outcomes in newly diagnosed IM.
  • To determine if KI-67-PI can predict tumor recurrence.

Main Methods

  • Single-center retrospective study of 463 IM in 457 surgically treated patients (January 2007 - August 2019).
  • Analysis of patient demographics, MRI parameters (location, volume, edema, necrosis), WHO grade, and histology.
  • Correlation of these factors with KI-67-PI and long-term follow-up data for tumor recurrence.

Main Results

  • Higher KI-67-PI was observed in males, older patients, and those with larger tumor volume, necrosis, and peritumoral edema.
  • KI-67-PI was significantly higher in atypical and anaplastic meningiomas compared to WHO grade 1 subtypes.
  • Patients with recurrent IM showed significantly higher KI-67-PI.
  • Convexity IM had higher KI-67-PI than frontobasal IM.

Conclusions

  • KI-67-PI is associated with aggressive features in intracranial meningiomas, including higher WHO grades, larger tumor size, and presence of edema/necrosis.
  • Elevated KI-67-PI is a significant predictor of tumor recurrence.
  • KI-67-PI may serve as a valuable indicator for adjuvant treatment decisions in IM patients.

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