Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Gene-Environment Interactions01:20

Gene-Environment Interactions

293
Gene expression is a dynamic process that is significantly influenced by environmental factors. This interaction underlies the complex nature of biological development and the phenotypic differences observed among individuals, even among those with identical genetic makeups. Factors such as radiation, temperature, behavior, nutrition, and stress play pivotal roles in determining how genes are expressed. The concept of the reaction range is central to understanding this interaction. It posits...
293
Background and Environment Affect Phenotype02:27

Background and Environment Affect Phenotype

6.5K
Although the genetic makeup of an organism plays a major role in determining the phenotype, there are also several environmental factors, such as temperature, oxygen availability, presence of mutagens, that can alter an organism’s phenotype.
An example of how genetic background affects phenotype can be seen in horses. The Extension gene in horses is responsible for their coat color. A wild-type gene (EE) produces black pigment in the coat, while a mutant gene (ee) produces red pigment. A...
6.5K
Epigenetic Regulation01:46

Epigenetic Regulation

31.0K
Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
31.0K
Human Genetics01:28

Human Genetics

559
Human genetics provides a profound framework for understanding the interplay between genetic predispositions and human psychology. At the heart of this discipline lies the study of how genes influence physical traits, behaviors, and susceptibility to diseases. Each person carries a unique genetic code that subtly or significantly shapes their psychological and behavioral landscape.
The complex relationship between genetics and psychology is observable through common biological components such...
559
Behavioral Genetics and Its Designs01:23

Behavioral Genetics and Its Designs

353
Behavior genetics explores how genetic inheritance influences human behavior. It focuses on how genes, passed from parents to offspring, contribute to the development of behavioral traits and tendencies. This branch of genetics seeks to understand the complex interplay between inherited genetic factors and environmental influences in shaping our behaviors.
The primary methodologies used in behavior genetics include family studies, twin studies, and adoption studies, each providing unique...
353
Genomic Imprinting and Inheritance02:30

Genomic Imprinting and Inheritance

34.3K
Diploid organisms inherit genetic material through chromosomes from both parents. Copies of the same gene are known as alleles. In most cases, both alleles are simultaneously expressed and allow various cellular processes to function optimally. If one of the alleles is missing or mutated, the expression of the other allele can compensate; however, this is not true for all genes.
The expression of some genes depends on which parent passed the gene to the offspring, through a phenomenon known as...
34.3K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Long-term outcome of combined liver-kidney transplantation: a single-center experience in China.

Hepato-gastroenterology·2008
Same author

Dolichol biosynthesis and its effects on the unfolded protein response and abiotic stress resistance in Arabidopsis.

The Plant cell·2008
Same author

In vitro interaction of terbinafine with itraconazole and amphotericin B against fungi causing chromoblastomycosis in China.

Medical mycology·2008
Same author

Regulation of autoinducer 2 production and luxS expression in a pathogenic Edwardsiella tarda strain.

Microbiology (Reading, England)·2008
Same author

Ischemic postconditioning inhibits apoptosis after focal cerebral ischemia/reperfusion injury in the rat.

Stroke·2008
Same author

Liver transplantation for hepatocellular carcinoma: Hangzhou experiences.

Transplantation·2008

Related Experiment Video

Updated: Jun 25, 2025

Optimized Analysis of DNA Methylation and Gene Expression from Small, Anatomically-defined Areas of the Brain
13:11

Optimized Analysis of DNA Methylation and Gene Expression from Small, Anatomically-defined Areas of the Brain

Published on: July 12, 2012

18.8K

Epigenetics and environmental health.

Min Zhang1, Ting Hu1, Tianyu Ma1,2

  • 1Key Laboratory of Cancer and Microbiome, State Key Laboratory of Molecular Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100021, China.

Frontiers of Medicine
|May 28, 2024
PubMed
Summary

Epigenetics, the study of gene expression changes without altering DNA sequence, is influenced by environmental factors and impacts health and disease. These reversible changes offer potential therapeutic targets for various conditions.

Keywords:
environmental exposureepigeneticshealthprevention and therapy

More Related Videos

A Protocol for Housing Mice in an Enriched Environment
09:30

A Protocol for Housing Mice in an Enriched Environment

Published on: June 8, 2015

18.3K
Methylated DNA Immunoprecipitation
21:24

Methylated DNA Immunoprecipitation

Published on: January 2, 2009

23.4K

Related Experiment Videos

Last Updated: Jun 25, 2025

Optimized Analysis of DNA Methylation and Gene Expression from Small, Anatomically-defined Areas of the Brain
13:11

Optimized Analysis of DNA Methylation and Gene Expression from Small, Anatomically-defined Areas of the Brain

Published on: July 12, 2012

18.8K
A Protocol for Housing Mice in an Enriched Environment
09:30

A Protocol for Housing Mice in an Enriched Environment

Published on: June 8, 2015

18.3K
Methylated DNA Immunoprecipitation
21:24

Methylated DNA Immunoprecipitation

Published on: January 2, 2009

23.4K

Area of Science:

  • Molecular Biology
  • Genetics
  • Environmental Health

Background:

  • Epigenetic modifications (DNA methylation, histone modifications, etc.) regulate gene expression and heredity.
  • Epigenetics is sensitive to environmental changes, influencing development, aging, and diseases like cancer and Alzheimer's.
  • Environmental exposures can induce epigenetic alterations impacting individual health outcomes.

Purpose of the Study:

  • To provide an overview of epigenetics in various diseases.
  • To summarize mechanisms of environmental exposure-induced epigenetic alterations.
  • To discuss therapeutic strategies targeting epigenetics.

Main Methods:

  • Literature review of epigenetic mechanisms and environmental influences.
  • Analysis of epigenetic crosstalk with genes and environmental factors.
  • Summary of current epigenetic drugs and dietary interventions.

Main Results:

  • Epigenetic changes are implicated in numerous diseases, including cardiovascular disease, Alzheimer's, and cancer.
  • Environmental factors significantly influence epigenetic modifications, affecting health.
  • Epigenetic modifications are reversible, presenting therapeutic opportunities.

Conclusions:

  • Epigenetic modifications play a crucial role in health and disease, influenced by environmental factors.
  • Reversible epigenetic changes offer promising avenues for disease prevention and treatment.
  • Understanding the interplay between environment, epigenetics, and genes is key for managing complex diseases.