Related Experiment Video

Updated: Jun 25, 2025

Intracerebroventricular and Intravascular Injection of Viral Particles and Fluorescent Microbeads into the Neonatal Brain
05:51

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Published on: July 24, 2016

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Vertical transmission of SARS-CoV-2 delta-variant in a preterm infant

Muhammad T K Zia1,2, Kishan Kumar1, Edmund La Gamma1,3

  • 1Department of Pediatrics, Maria Fareri Children's Hospital at Westchester Medical Center, New York Medical College, Valhalla, NY, USA.

BMC Infectious Diseases
|May 28, 2024
PubMed
Abstract

Insights

The SARS-CoV-2 delta variant can replicate in the placenta, leading to vertical transmission in preterm infants. This case highlights the ongoing risks of COVID-19 variants during pregnancy.

Area of Science:

  • Virology
  • Perinatal Medicine
  • Infectious Diseases

Background:

  • The impact of SARS-CoV-2 variants on perinatal health requires further investigation.
  • Vertical transmission of the original SARS-CoV-2 strain is rare, but data on delta-variant transmission is limited.

Observation:

  • A case of a preterm male neonate born to a mother with SARS-CoV-2 infection is presented.
  • The neonate tested positive for SARS-CoV-2 from birth for three weeks.
  • Placental analysis revealed a high viral load and evidence of active viral replication.

Findings:

  • Active replication of the SARS-CoV-2 delta variant was confirmed in the placenta.
  • The findings suggest a link between placental viral replication and vertical transmission.

Implications:

  • This case demonstrates vertical transmission of the SARS-CoV-2 delta variant in a preterm infant.
  • Highlights the potential for severe outcomes in neonates due to novel viral variants.
Keywords:
COVID-19Delta variantPreterm infantSARS-CoV-2Vertical transmission

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