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Updated: Jun 25, 2025
11:51
Systemic and Local Drug Delivery for Treating Diseases of the Central Nervous System in Rodent Models
Published on: August 16, 2010
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Oral administration microrobots for drug delivery
An Ren1,2, Jiarui Hu1,2, Changwei Qin1,2
1State Key Laboratory of Fluid Power and Mechatronic Systems, Zhejiang University, Hangzhou 310058, China.
Bioactive Materials
|May 29, 2024
Summary
Drug delivery microrobots offer promising solutions for oral treatments, overcoming challenges in bioavailability and targeted delivery within the gastrointestinal tract. This review categorizes microrobots by propulsion, discussing design, materials, and clinical translation prospects.
Area of Science:
- Biomedical Engineering
- Materials Science
- Nanotechnology
Background:
- Oral drug delivery faces challenges with biologics bioavailability and targeted gastrointestinal therapy.
- Microrobots offer flexible locomotion for enhanced oral drug delivery applications.
Purpose of the Study:
- To review recent advancements in oral drug delivery microrobots.
- To categorize microrobots based on driving modes and discuss their design, materials, and clinical translation.
Main Methods:
- Categorization of microrobots into magnetic-controlled, anchored, self-propelled, and biohybrid types.
- Review of materials science, engineering, and control systems involved in microrobot design.
- Analysis of advantages, limitations, and clinical translation challenges.
Main Results:
- Oral drug delivery microrobots show potential to overcome bioavailability and targeting issues.
- Different microrobot types exhibit unique advantages and limitations for specific applications.
- Guideline for designing oral drug delivery microrobots provided.
Conclusions:
- Microrobots represent a significant advancement in oral drug delivery systems.
- Addressing safety and clinical translation challenges is crucial for future development.
- Further research is needed to optimize microrobot design and facilitate clinical adoption.
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