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Updated: Jun 25, 2025
08:02
Th17 Inflammation Model of Oropharyngeal Candidiasis in Immunodeficient Mice
Published on: February 18, 2015
10.0K
Neonatal innate immunity response in invasive candidiasis.
J A G Suárez1, R J N Calumby2, D P Silva2
1Universidade Federal de Ouro Preto - UFOP, Ouro Preto, MG, Brasil.
Summary
Newborns
Area of Science:
- Immunology
- Neonatal Medicine
- Infectious Diseases
Background:
- Healthcare-associated infections, particularly Candida spp., are common in critically ill newborns.
- Neonatal innate immune defense mechanisms against invasive candidiasis are not fully understood.
Purpose of the Study:
- To delineate the innate immune mechanisms protecting neonates from invasive candidiasis.
- To enhance understanding of neonatal immunology in combating fungal infections.
Main Methods:
- Integrative literature review (2002-2020).
- Searched Scopus, Scifinder, Medline, Web of Science, ScienceDirect, and Scielo.
- Keywords: Innate Immunity, Invasive Candidiasis, Infant Newborn.
Main Results:
- Neonatal innate immunity involves recognition, signaling, and response initiation.
- Key mechanisms include antimicrobial peptides, phagocytosis, reactive oxygen species, and Pattern Recognition Receptors (PRRs).
- Complex cell signaling pathways are crucial for defense.
Conclusions:
- This review clarifies neonatal innate immune responses to invasive Candida infections.
- Enhanced knowledge can inform strategies to reduce neonatal mortality from disseminated fungal infections.
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