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Generation of Recombinant Arenavirus for Vaccine Development in FDA-Approved Vero Cells
Published on: August 1, 2013
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Subgenomic flavivirus RNA as key target for live-attenuated vaccine development
Kristel Doets1, Gorben P Pijlman1
1Wageningen University and Research, Laboratory of Virology, Wageningen, the Netherlands.
Journal of Virology
|May 29, 2024
Abstract
None:
Live-attenuated flavivirus vaccines confer long-term protection against disease, but the design of attenuated flaviviruses does not follow a general approach. The non-coding, subgenomic flavivirus RNA (sfRNA) is produced by all flaviviruses and is an essential factor in viral pathogenesis and transmission. We argue that modulating sfRNA expression is a promising, universal strategy to finetune flavivirus attenuation for developing effective flavivirus vaccines of the future.

