Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Efficacy and Safety Differences Between Abiraterone and Enzalutamide in Patients with Metastatic Castration-Resistant Prostate Cancer: A Systematic Review and Meta-analysis of Real-World Studies.

Targeted oncology·2026

Same author

Continuous glucose monitoring for prediabetes classification in a large real-world cohort: Comparison with HbA1c and fasting plasma glucose.

Diabetes research and clinical practice·2026

Same author

MicroRNA-210 level as a biomarker for pre-eclampsia severity: A systematic review and meta-analysis.

International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics·2026

Same author

Complete denture soft liners improve bite force, mastication, and life quality: A systematic review and meta-analysis.

Journal of prosthodontics : official journal of the American College of Prosthodontists·2026

Same author

Semiological features of epilepsy seizures and paroxysmal non-epileptic events in children: A systematic review and meta-analysis.

Developmental medicine and child neurology·2026

Same author

Clinical practice patterns in the pre-endoscopic management of individuals presenting with acute upper gastrointestinal bleeding: results of an international survey.

Therapeutic advances in gastroenterology·2026

Search research articles

Related Experiment Video

Updated: Jun 25, 2025

Neuronavigation and Laparoscopy Guided Ventriculoperitoneal Shunt Insertion for the Treatment of Hydrocephalus

Neuronavigation and Laparoscopy Guided Ventriculoperitoneal Shunt Insertion for the Treatment of Hydrocephalus

Published on: October 14, 2022

Antibiotic-Impregnated Ventriculoperitoneal Shunts Decrease Bacterial Shunt Infection: A Systematic Review and

Janka Kovács^1,2, Vanda Máté^1,2, Mahmoud Obeidat¹

¹Centre for Translational Medicine, Semmelweis University, Budapest , Hungary.

|May 29, 2024

Summary

Antibiotic-impregnated shunt catheters (AISCs) significantly reduce bacterial infections in hydrocephalus patients. While not statistically significant, AISCs showed a trend toward decreasing shunt failure rates compared to standard shunts.

More Related Videos

In Vivo Mouse Model of Spinal Implant Infection

In Vivo Mouse Model of Spinal Implant Infection

Published on: June 23, 2020

A Retrospective Study on Endoscopic Surgery for the Treatment of Paravertebral Abscess in Spinal Tuberculosis Patients

A Retrospective Study on Endoscopic Surgery for the Treatment of Paravertebral Abscess in Spinal Tuberculosis Patients

Published on: October 25, 2024

Related Experiment Videos

Last Updated: Jun 25, 2025

Neuronavigation and Laparoscopy Guided Ventriculoperitoneal Shunt Insertion for the Treatment of Hydrocephalus

Neuronavigation and Laparoscopy Guided Ventriculoperitoneal Shunt Insertion for the Treatment of Hydrocephalus

Published on: October 14, 2022

In Vivo Mouse Model of Spinal Implant Infection

In Vivo Mouse Model of Spinal Implant Infection

Published on: June 23, 2020

A Retrospective Study on Endoscopic Surgery for the Treatment of Paravertebral Abscess in Spinal Tuberculosis Patients

A Retrospective Study on Endoscopic Surgery for the Treatment of Paravertebral Abscess in Spinal Tuberculosis Patients

Published on: October 25, 2024

Area of Science:

Neurosurgery
Infectious Disease Prevention
Medical Device Technology

Background:

Hydrocephalus management often involves shunt placement, which carries a risk of bacterial infection.
Shunt-associated infections can lead to significant morbidity, mortality, and increased healthcare costs.
Antibiotic-impregnated shunt catheters (AISCs) are designed to mitigate these risks by inhibiting microbial growth.

Approach:

A comprehensive meta-analysis was performed, searching PubMed, Scopus, and CENTRAL databases.
Included randomized controlled trials and observational studies published up to November 2022.
Analyzed the primary outcome of bacterial infection rates and the secondary outcome of shunt failure rates using random-effects models.

Key Points:

The meta-analysis included 27 articles encompassing 27,266 shunt operations.
AISCs demonstrated a statistically significant reduction in bacterial shunt infections (OR = 0.42; 95% CI: 0.33-0.54).
A trend favoring AISCs was observed for reducing shunt failure (OR = 0.73; 95% CI: 0.51-1.06).

Conclusions:

AISCs are significantly effective in reducing the incidence of bacterial ventriculoperitoneal-shunt infections.
Evidence suggests a potential benefit of AISCs in decreasing shunt failure rates.
These findings support the use of AISCs for improved patient outcomes in hydrocephalus management.