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  11. Diagnostic Efficacy Of Urinary Neutrophil Gelatinase-associated Lipocalin And Kidney Injury Molecule-1 For Early Detection Of Acute Kidney Injury In Dogs With Leptospirosis Or Babesiosis

Diagnostic efficacy of urinary neutrophil gelatinase-associated lipocalin and kidney injury molecule-1 for early detection of acute kidney injury in dogs with leptospirosis or babesiosis

M Asma Idress1, P M Deepa2, R L Rathish1

  • 1Department of Veterinary Epidemiology and Preventive Medicine, College of Veterinary and Animal Sciences, Kerala Veterinary and Animal Sciences University, Pookode, Wayanad, Kerala, India.

Veterinary Research Communications
|May 29, 2024

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View abstract on PubMed

Summary
This summary is machine-generated.

Urinary Neutrophil Gelatinase-Associated Lipocalin (uNGAL) and Kidney Injury Molecule-1 (uKIM-1) show promise as early diagnostic markers for acute kidney injury (AKI) in dogs. These biomarkers are particularly useful in detecting renal damage even before traditional indicators become apparent.

Area of Science:

  • Veterinary Medicine
  • Biomarker Discovery
  • Renal Pathophysiology

Background:

  • Acute Kidney Injury (AKI) poses a significant diagnostic challenge in canine leptospirosis and babesiosis.
  • Traditional biomarkers like serum creatinine and blood urea nitrogen may not detect early renal damage effectively.

Purpose of the Study:

  • To evaluate the diagnostic efficacy of urinary Neutrophil Gelatinase-Associated Lipocalin (uNGAL) and urinary Kidney Injury Molecule-1 (uKIM-1) in dogs with AKI.
  • To compare novel urinary biomarkers with traditional serum markers for AKI detection.

Main Methods:

  • Dogs with leptospirosis or babesiosis were assessed for AKI based on serum creatinine levels and International Renal Interest Society (IRIS) guidelines.
  • Urinary NGAL, urinary KIM-1, serum creatinine, and blood urea nitrogen levels were measured and compared to control groups.
Keywords:
Acute kidney injuryBabesiosisCanineKIM-1

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  • Statistical analysis was performed to determine significant differences in biomarker concentrations across AKI grades.

    • Main Results:

    • Elevated levels of uNGAL and uKIM-1 were observed in dogs with IRIS grade I AKI (P < 0.001).
    • These novel biomarkers demonstrated significant diagnostic potential, especially in non-azotemic AKI cases.
    • uNGAL and uKIM-1 showed higher sensitivity in detecting early renal damage compared to traditional markers.

    Conclusions:

    • Urinary NGAL and KIM-1 are valuable early indicators of renal damage in dogs with AKI.
    • These biomarkers offer improved diagnostic capabilities for early AKI detection in veterinary clinical settings.
    • Further research with larger cohorts is recommended to validate their diagnostic accuracy across diverse AKI etiologies.
    Leptospirosis
    NGAL