Quality of Life and Nutritional Outcomes of Stomach-Preserving Surgery for Early Gastric Cancer: A Secondary Analysis of the SENORITA Randomized Clinical Trial
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View abstract on PubMed
Summary
This summary is machine-generated.Stomach-preserving surgery offers better long-term quality of life and nutritional outcomes compared to standard gastrectomy for early-stage gastric cancer patients. This approach may aid treatment decisions.
Area Of Science
- Surgical Oncology
- Gastroenterology
- Clinical Nutrition
Background
- The Sentinel Node Oriented Tailored Approach (SENORITA) trial compared laparoscopic sentinel node navigation surgery (LSNNS) with laparoscopic standard gastrectomy (LSG).
- Limited data exists on the quality of life (QoL) and nutritional outcomes specifically for patients undergoing stomach-preserving surgery within the LSNNS group.
Purpose Of The Study
- To compare long-term QoL and nutritional outcomes between stomach-preserving surgery and standard gastrectomy.
- To identify factors associated with poor QoL in patients who underwent stomach-preserving surgery.
Main Methods
- Secondary analysis of the SENORITA randomized clinical trial (NCT01804998).
- Included patients who underwent stomach-preserving surgery (LSNNS group) or standard gastrectomy (LSG group).
- Assessed QoL using EORTC QLQ-C30 and STO22; nutritional status via BMI, hemoglobin, protein, and albumin levels up to 5 years post-surgery.
Main Results
- The stomach-preserving group showed significantly better QoL scores at 3 months postoperatively across multiple domains, including physical function and appetite.
- At 1 year, the stomach-preserving group had higher BMI, hemoglobin, albumin, and protein levels.
- Tumor location was associated with better global health status and reduced eating restrictions; segmental resection was linked to increased diarrhea and eating restrictions in the long term.
Conclusions
- Stomach-preserving surgery following sentinel node evaluation is associated with superior long-term QoL and nutritional outcomes compared to standard gastrectomy.
- These findings support stomach-preserving surgery as a viable option for selected early-stage gastric cancer patients, potentially improving treatment decision-making.
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