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Updated: Jun 25, 2025

Facile Preparation of 2Z,4E-Dienamides by the Olefination of Electron-deficient Alkenes with Allyl Acetate
Published on: June 21, 2017
Aminoselenation and Dehydroaromatization of Cyclohexanones with Anilines and Diselenides
Lin Zhao1, Yujie Weng1, Xinyu Zhou1
1School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou 325035, China.
Abstract:
A three-component cascade reaction involving cyclohexanones, anilines, and diaryl diselenides under metal-free conditions is reported. The ortho-selenation of cyclohexanones with diaryl diselenides, followed by sequential dehydroaromatization with anilines, enables the preparation of a variety of o-selanyl anilines in moderate to excellent yields. This innovative transformation is notable for its excellent tolerance of functional groups and is suitable for the late-stage modification of complex pharmaceuticals.
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