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The JAK-STAT Signaling Pathway

The JAK-STAT Signaling Pathway

Several cytokine receptors have tightly bound Janus kinase or JAK proteins attached at their cytosolic tail. Small signaling molecules such as cytokines, growth hormones, or prolactins bind to the cytokine receptors and initiate their dimerization. The dimerization brings the cytosolic JAKs together that trans-phosphorylate and activates each other. The activated JAKs now phosphorylate cytosolic tails of the cytokine receptors, which serve as binding sites for adaptor proteins such as SH2...

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JAK Inhibition Immunotherapy for APS-1

¹From the Department of Microbiology, Immunology, and Molecular Genetics and the Department of Pediatrics, David Geffen School of Medicine at University of California, Los Angeles, Los Angeles.

The New England Journal of Medicine

|May 29, 2024

Summary

No abstract available in PubMed .

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