Exploring the impact of hydrogen sulfide on hematologic malignancies: A review

Hydrogen sulfide (H₂S) is one of the three most crucial gaseous messengers in the body. The discovery of H₂S donors, coupled with its endogenous synthesis capability, has sparked hope for the treatment of hematologic malignancies. In the last decade, the investigation into the impact of H₂S has expanded, particularly within the fields of cardiovascular function, inflammation, infection, and neuromodulation. Hematologic malignancies refer to a diverse group of cancers originating from abnormal proliferation and differentiation of blood-forming cells, including leukemia, lymphoma, and myeloma. In this review, we delve deeply into the complex interrelation between H₂S and hematologic malignancies. In addition, we comprehensively elucidate the intricate molecular mechanisms by which both H₂S and its donors intricately modulate the progression of tumor growth. Furthermore, we systematically examine their impact on pivotal aspects, encompassing the proliferation, invasion, and migration capacities of hematologic malignancies. Therefore, this review may contribute novel insights to our understanding of the prospective therapeutic significance of H₂S and its donors within the realm of hematologic malignancies.