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Related Concept Videos

Tumor Immunotherapy01:27

Tumor Immunotherapy

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Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
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Targeted Cancer Therapies02:57

Targeted Cancer Therapies

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The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
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Related Experiment Video

Updated: Jun 25, 2025

Magnetic-, Acoustic-, and Optical-Triple-Responsive Microbubbles for Magnetic Hyperthermia and Pothotothermal Combination Cancer Therapy
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Unzippable Siamese Nanoparticles for Programmed Two-Stage Cancer Immunotherapy.

Mei Long1, Yanfeng Zhou1, Daoxia Guo1

  • 1School of Public Health, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China.

Advanced Materials (Deerfield Beach, Fla.)
|May 29, 2024
PubMed
Summary

Novel Siamese nanoparticles deliver epigenetic drugs and an inhibitor to solid tumors, enhancing anti-tumor immunity and overcoming resistance to immunotherapy by targeting both cancer cells and myeloid-derived suppressor cells.

Keywords:
MDSC reprogrammingSiamese nanoparticlesepigenetic therapyinterparticle DNA reactionssolid tumors

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Area of Science:

  • Oncology
  • Immunology
  • Nanotechnology
  • Drug Delivery

Background:

  • Epigenetic drugs (epi-drugs) show promise in cancer therapy by inducing cell death and immune responses.
  • Limited success in solid tumors is partly due to the induction of immunosuppressive myeloid-derived suppressor cells (MDSCs).

Purpose of the Study:

  • To develop a targeted nanoparticle system for dual delivery of an epi-drug and an MDSC inhibitor.
  • To overcome the immunosuppressive tumor microenvironment and enhance anti-tumor immunity.

Main Methods:

  • Development of dissociable Siamese nanoparticles (SIANPs) for targeted delivery.
  • Assembly of SIANPs via DNA annealing and triggered detachment in the tumor microenvironment.
  • Co-delivery of epi-drug CM-272 to tumor cells and Ibrutinib to MDSCs.

Main Results:

  • SIANPs induced immunogenic cell death in tumor cells and restrained MDSC immunosuppression.
  • Enhanced dendritic cell maturation and CD8+ T cell activation were observed.
  • The approach overcame resistance to immune checkpoint blockade therapy.

Conclusions:

  • Dissociable nanoparticles offer a dual-targeting strategy for cancer immunotherapy.
  • This approach enhances anti-tumor immunity and overcomes resistance to existing therapies.
  • Paves a new way for employing epi-drugs in cancer immunotherapy.