Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Amyloid Fibrils03:03

Amyloid Fibrils

9.5K
Amyloid fibrils are aggregates of misfolded proteins.  Under most circumstances, misfolded proteins are either refolded by chaperone proteins or degraded by the proteasome. However, in the case of a mutation or a disease, these proteins can accumulate to form large clusters and often further assemble to form elongated fibers, called fibrils. 
Amyloid deposits were observed as early as 1639 in the liver and the spleen.   In 1854, Rudolph Virchow performed iodine staining,...
9.5K
Alzheimer's Disease: Overview01:26

Alzheimer's Disease: Overview

462
Alzheimer's Disease (AD) is a continually advancing neurodegenerative disorder, distinguished by escalating memory loss, cognitive dysfunction, and dementia. The disease unfolds in three stages: preclinical, mild cognitive impairment (MCI), and dementia. Its onset is insidious, and the progression gradual, with the cause not well explained by other disorders.
The clinical diagnosis of AD hinges on the presence of memory and other cognitive impairments. Biomarkers, such as changes in Aβ...
462
Alzheimer's Disease: Treatment01:22

Alzheimer's Disease: Treatment

179
Alzheimer's Disease (AD), a neurodegenerative disorder, is pathologically identified by amyloid plaques and neurofibrillary tangles composed of tau protein. AD pharmacotherapy aims to manage cognitive symptoms, delay disease progression, and treat behavioral symptoms. The treatment is primarily symptomatic and palliative, with no definitive disease-modifying therapy available. Cholinesterase inhibitors, including donepezil (Aricept), rivastigmine (Exelon), and galantamine (Razadyne), are...
179

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A bifunctional CPG2-anti PD-L1 fusion protein combining specific tumor targeting and enzyme-mediated prodrug activation.

International journal of biological macromolecules·2026
Same author

Comparative analysis of SUMO and his-tag fusion for soluble expression of the SARS-CoV-2 omicron RBD in E. coli.

Protein expression and purification·2025
Same author

The association between periostin and tumor microenvironment: a promising cancer prognostic biomarker and therapeutic target to combat tumor progression and chemoresistance.

Cancer cell international·2025
Same author

Design, synthesis, and evaluation of the effect of potential peptides against CD38: An in silico and in vitro study.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie·2025
Same author

Therapeutic potential of flavonoids against α-synuclein aggregation in Parkinson's Disease: Integrative in silico and in vitro analysis.

European journal of pharmacology·2025
Same author

Recent advances in surface plasmon resonance for the detection of ovarian cancer biomarkers: a thorough review.

Mikrochimica acta·2024

Related Experiment Video

Updated: Jun 25, 2025

Rapid Generation of Amyloid from Native Proteins In vitro
05:48

Rapid Generation of Amyloid from Native Proteins In vitro

Published on: December 5, 2013

6.2K

Functional amyloids.

Mansoureh Mirza Agha1, Elaheh Tavili1, Bahareh Dabirmanesh1

  • 1Department of Biochemistry, Faculty of Biological Sciences, Tarbiat Modares University, Tehran, Iran.

Progress in Molecular Biology and Translational Science
|May 29, 2024
PubMed
Summary

Emerging research reveals that amyloids, once considered harmful, play crucial functional roles in diverse organisms. These non-pathogenic amyloids are vital for essential biological processes across evolution.

Keywords:
BiofilmEukaryotesFunctional amyloidMicroorganismsPrionsToxin and antimicrobial

More Related Videos

Interactions with and Membrane Permeabilization of Brain Mitochondria by Amyloid Fibrils
00:15

Interactions with and Membrane Permeabilization of Brain Mitochondria by Amyloid Fibrils

Published on: September 28, 2019

5.9K
Biochemical Purification and Proteomic Characterization of Amyloid Fibril Cores from the Brain
09:00

Biochemical Purification and Proteomic Characterization of Amyloid Fibril Cores from the Brain

Published on: April 28, 2022

3.1K

Related Experiment Videos

Last Updated: Jun 25, 2025

Rapid Generation of Amyloid from Native Proteins In vitro
05:48

Rapid Generation of Amyloid from Native Proteins In vitro

Published on: December 5, 2013

6.2K
Interactions with and Membrane Permeabilization of Brain Mitochondria by Amyloid Fibrils
00:15

Interactions with and Membrane Permeabilization of Brain Mitochondria by Amyloid Fibrils

Published on: September 28, 2019

5.9K
Biochemical Purification and Proteomic Characterization of Amyloid Fibril Cores from the Brain
09:00

Biochemical Purification and Proteomic Characterization of Amyloid Fibril Cores from the Brain

Published on: April 28, 2022

3.1K

Area of Science:

  • Cell Biology
  • Biochemistry
  • Evolutionary Biology

Background:

  • Traditionally, amyloids were primarily associated with pathological conditions.
  • Recent scientific discoveries indicate that amyloids also perform essential physiological functions.
  • These functional amyloids are conserved across a wide range of species, from microorganisms to mammals.

Purpose of the Study:

  • To explore the emerging evidence for functional amyloids.
  • To highlight the diverse roles of non-pathogenic amyloids in biological systems.
  • To provide a comprehensive overview of functional amyloids in microorganisms, animals, and plants.

Main Methods:

  • Review of existing scientific literature on amyloid biology.
  • Analysis of documented cases of functional amyloids in various organisms.
  • Synthesis of findings to illustrate the evolutionary significance of functional amyloids.

Main Results:

  • Functional amyloids contribute to vital processes such as biofilm formation, melanin synthesis, storage, information transfer, and memory.
  • The discovery of numerous functional amyloids across different kingdoms of life validates their widespread biological importance.
  • Non-pathogenic amyloids represent a significant area of study in understanding conserved biological mechanisms.

Conclusions:

  • Amyloids possess a dual nature, with both pathogenic and crucial functional roles.
  • The study of functional amyloids offers insights into conserved biological processes and evolutionary strategies.
  • Further research into functional amyloids is warranted to fully understand their impact on cell biology and physiology.