Related Experiment Video

Updated: Jun 25, 2025

Benefits of Cardiac Resynchronization Therapy in an Asynchronous Heart Failure Model Induced by Left Bundle Branch Ablation and Rapid Pacing
12:45

Benefits of Cardiac Resynchronization Therapy in an Asynchronous Heart Failure Model Induced by Left Bundle Branch Ablation and Rapid Pacing

Published on: December 11, 2017

10.5K

Arrhythmia-Induced Cardiomyopathy: JACC State-of-the-Art Review

Pouria Shoureshi1, Alex Y Tan1, Jayanthi Koneru2

  • 1Virginia Commonwealth University/Pauley Heart Center, Richmond, Virginia, USA; Central Virginia Veterans Affair Health Care System, Richmond, Virginia, USA.

Journal of the American College of Cardiology
|May 29, 2024
PubMed

Insights

Arrhythmia-induced cardiomyopathy (AiCM) is a reversible condition caused by heart rhythm problems. Early diagnosis and treatment of these arrhythmias can restore heart function and improve patient outcomes.

Area of Science:

  • Cardiology
  • Electrophysiology
  • Heart Failure Research

Background:

  • Arrhythmias, including tachycardias, atrial fibrillation, and premature ventricular contractions, are common in heart failure.
  • These arrhythmias can lead to a reversible form of dilated cardiomyopathy, termed arrhythmia-induced cardiomyopathy (AiCM).
  • Individual susceptibility to AiCM despite similar arrhythmia burdens remains an area of investigation.

Purpose of the Study:

  • To explore the relationship between arrhythmias and left ventricular dysfunction.
  • To identify key indicators for considering AiCM in clinical practice.
  • To outline diagnostic and therapeutic strategies for AiCM.

Main Methods:

  • Clinical observation and diagnosis of patients with heart failure and arrhythmias.
  • Assessment of left ventricular function and response to arrhythmia elimination.
  • Evaluation of patient comorbidities and preferences for guiding therapy.

Main Results:

  • AiCM is a significant cause of reversible left ventricular dysfunction.
  • Specific criteria (mean heart rate >100 bpm, atrial fibrillation, or PVC burden >10%) suggest AiCM.
  • Reversal of cardiomyopathy is confirmed by the elimination of the causative arrhythmia.

Conclusions:

  • Accurate diagnosis and treatment of AiCM can significantly improve patient quality of life and clinical outcomes.
  • Effective management of AiCM can reduce hospital admissions and healthcare costs.
  • Ongoing monitoring is crucial for patients with persistent myocardial abnormalities after functional recovery.

Keywords:
arrhythmiacardiomyopathyheart failureleft ventricular dysfunctionpremature ventricular contractionssupraventricular tachycardia

More Related Videos

Tissue Preparation Techniques for Contrast-Enhanced Micro Computed Tomography Imaging of Large Mammalian Cardiac Models with Chronic Disease12:15

Tissue Preparation Techniques for Contrast-Enhanced Micro Computed Tomography Imaging of Large Mammalian Cardiac Models with Chronic Disease

Published on: February 8, 2022

2.5K
Isolation of Atrial Cardiomyocytes from a Rat Model of Metabolic Syndrome-related Heart Failure with Preserved Ejection Fraction08:31

Isolation of Atrial Cardiomyocytes from a Rat Model of Metabolic Syndrome-related Heart Failure with Preserved Ejection Fraction

Published on: July 26, 2018

10.1K

Related Concept Videos

Mechanism of Cardiac Arrhythmias01:28

Mechanism of Cardiac Arrhythmias

Arrhythmias are irregular heart rhythms occurring when the heart's electrical impulses become abnormal. These disturbances can lead to various symptoms, depending on their severity and the underlying cause. Some common factors contributing to arrhythmias include hypoxia, ischemia, electrolyte imbalances, excessive catecholamine exposure, drug toxicity, and muscle overstretching. Arrhythmias can be classified into two main types based on the rate and site of origin of abnormal heart rhythms.
911
Disturbances in Heart Rhythm01:28

Disturbances in Heart Rhythm

Arrhythmia or dysrhythmia refers to an abnormal heart rhythm caused by a defect in the heart's conduction system. It can cause the heart to beat irregularly, too quickly, or too slowly, leading to symptoms like chest pain, shortness of breath, and fainting. Factors such as stress, caffeine, alcohol, nicotine, cocaine, certain drugs, congenital defects, diseases, and electrolyte abnormalities can trigger arrhythmias.
Arrhythmias are categorized by their speed, rhythm, and origin. A slow...
936
Electrophysiology of Normal Cardiac Rhythm01:19

Electrophysiology of Normal Cardiac Rhythm

The normal cardiac rhythm is a synchronized electrical activity that facilitates the regular and coordinated contraction of the heart muscle. This process is essential for efficient blood circulation throughout the body. The fundamental elements involved in establishing and maintaining this rhythm include the unique electrical properties of cardiac muscle cells, the sinoatrial (SA) node's pacemaker function, the specialized conducting system, and the ionic mechanisms underlying each phase...
3.3K
Ischemic Heart Disease: Overview01:17

Ischemic Heart Disease: Overview

Ischemic heart disease occurs when the heart's blood supply dwindles, causing an ominous lack of oxygen and nutrients. This deficiency, stemming from reduced or obstructed blood flow, spells danger, leading to heart muscle damage and dysfunction.
Atherosclerosis, the primary malefactor, orchestrates this dangerous condition. It manifests as the accumulation of fatty deposits, akin to insidious plaques, within arterial walls. As time elapses, these plaques metamorphose, hardening and...
1.3K
Pathophysiology of Cardiac Performance01:29

Pathophysiology of Cardiac Performance

Typical heart performance is influenced by heart rate, rhythm, myocardial contraction, and metabolism or blood flow. The cardiac muscle exhibits distinct electrophysiological features, including pacemaker activity and calcium channel control, which play a vital role in the heart's response to various drugs. The autonomic nervous system, comprising the sympathetic and parasympathetic branches, regulates heart rate. Sympathetic activation increases heart rate, while parasympathetic activation...
635
Pathophysiology of Heart Failure01:17

Pathophysiology of Heart Failure

Heart failure (HF) is a progressive syndrome involving ventricles that leads to inadequate cardiac output. It can be classified based on location and output or ejection fraction. Ejection fraction (EF) is an essential measurement in the diagnosis and surveillance of HF. Reduced EF corresponds to systolic heart failure (HFrEF). However, HF with preserved ejection fraction (HFpEF) is becoming increasingly prevalent. Also known as diastolic HF, this form of HF is related to aging. The...
1.6K