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Updated: Jun 25, 2025
The Influence of Liver Resection on Intrahepatic Tumor Growth
Published on: April 9, 2016
A preoperative model to predict overall survival in patients with hepatoma undergoing resection
Wei-Feng Li1, Sin-Hua Moi2, Yueh-Wei Liu1
1Liver Transplantation Center and Department of Surgery, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung, Taiwan.
Background:
We aimed to develop a preoperative model to predict overall survival (OS) in patients with hepatoma undergoing liver resection (LR).
Methods:
Patients who underwent LR for Barcelona Clinic Liver Cancer (BCLC) stage 0, A, or B hepatoma were enrolled. Tumor burden score (TBS) scores were determined using the following equation: TBS (Pinna et al., 2018) 2 = (largest tumor size [in cm])(Pinna et al., 2018) 2 + (tumor number) (Pinna et al., 2018) 22. The cutoff values for radiographic TBS were based on our recently published paper: low, <2.6; medium, 2.6-7.9; high, >7.9.
Results:
Multivariate analysis showed that radiographic TBS (low: referent; medium: HR = 2.89; 95 % CI: 1.60-5.21; p < 0.001; high, HR = 7.60; 95 % CI: 3.80-15.2; p < 0.001), AFP (<400 ng/mL: referent; ≧400 ng/mL: HR = 1.67, 95 % CI: 1.11-2.52, p = 0.014), and cirrhosis (absence: referent; presence: HR = 1.88, 95 % CI: 1.30-2.72, p < 0.001) were associated with OS. A simplified risk score was superior to BCLC system in concordance index (0.688 vs. 0.623).
Conclusions:
We have developed a preoperative model that performs better in predicting OS than the BCLC system.
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