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Updated: Jun 25, 2025
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DIPLOMA Approach for Standardized Pathology Assessment of Distal Pancreatectomy Specimens
Published on: February 1, 2020
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The impact of cirrhosis on short and long postoperative outcomes after distal pancreatectomy
Benjamin Coinsin1, Thibault Durin1, Ugo Marchese2
1Department of Digestive Surgery and Transplantation, Lille University Hospital, France.
Surgery
|May 29, 2024
Summary
Distal pancreatectomy in patients with compensated cirrhosis shows similar postoperative outcomes and survival rates compared to those without cirrhosis. However, cirrhotic patients experienced longer operative times.
Area of Science:
- Hepatology
- Surgical Oncology
- Gastroenterology
Background:
- The impact of cirrhosis on distal pancreatectomy outcomes remains largely unreported.
- Evaluating postoperative results in cirrhotic patients undergoing this procedure is crucial.
Purpose of the Study:
- To assess the safety and outcomes of distal pancreatectomy in patients with cirrhosis.
- To compare postoperative complications and survival between cirrhotic and non-cirrhotic patients.
Main Methods:
- Retrospective, multicentric study of patients undergoing distal pancreatectomy (2008-2020).
- Cirrhotic patients (n=32) were matched 1:4 with non-cirrhotic controls (n=128).
- Primary endpoint: severe morbidity (Clavien-Dindo grade ≥III); secondary endpoints: complications and survival.
Main Results:
- Severe morbidity rates were comparable (28.13% vs 25.75%, P=.11).
- Operative time was significantly longer in the cirrhotic group (P=.01).
- Similar rates of pancreatic fistula, hemorrhage, reoperation, mortality, and long-term survival were observed.
Conclusions:
- Distal pancreatectomy is feasible in patients with compensated cirrhosis when performed in high-volume centers.
- The procedure demonstrates acceptable safety profiles and survival outcomes in this patient population.
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