Enhancing the human health and lifespan: a targeted strategy emphasizing statins

Area of Science:

• Gerontology
• Pharmacology
• Public Health

Background:

• Growing interest in interventions to mitigate age-related diseases.
• Statins are widely studied agents for promoting health across diverse populations.
• Epidemiological studies investigate statins' effects on numerous health endpoints.

Purpose of the Study:

• To assess the broad-spectrum health benefits of statins.
• To evaluate statins' potential as a public health strategy.
• To explore mechanisms and address adverse effects of statin use.

Main Methods:

• Large-scale epidemiological studies.
• Analysis of cell and animal models.
• Review of proposed underlying mechanisms of action.

Main Results:

• Statin treatment consistently reduces the incidence and severity of non-communicable diseases, contagious pathologies, and high-mortality cancers by 20-50%.
• Evidence from epidemiological, cell, and animal studies supports statins' broad salutary effects.
• Activation of Nrf2 is a proposed key mechanism contributing to statins' benefits.

Conclusions:

• Statins demonstrate a wide range of positive health effects, impacting numerous diseases and cancers.
• Statin's capacity to activate Nrf2 and their bioavailability contribute to their health benefits.
• Exploring statins as a public health strategy, with management of side effects like myalgia, is warranted.