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Magnetic Resonance Imaging

Magnetic Resonance Imaging

Magnetic resonance imaging (MRI) is a noninvasive medical imaging technique based on a phenomenon of nuclear physics discovered in the 1930s, in which matter exposed to magnetic fields and radio waves was found to emit radio signals. In 1970, a physician and researcher named Raymond Damadian noticed that malignant (cancerous) tissue gave off different signals than normal body tissue. He applied for a patent for the first MRI scanning device in clinical use by the early 1980s. The early MRI...

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Related Experiment Video

Updated: Jun 25, 2025

Combined Near-infrared Fluorescent Imaging and Micro-computed Tomography for Directly Visualizing Cerebral Thromboemboli

Combined Near-infrared Fluorescent Imaging and Micro-computed Tomography for Directly Visualizing Cerebral Thromboemboli

Published on: September 25, 2016

Making acute ischemic stroke thrombi visible in MRI imaging.

Aglaé Velasco Gonzalez^1,2, Boris Buerke³, Dennis Görlich⁴

¹Clinic for Radiology, University of Muenster, Albert-Schweitzer-Campus 1, Gebäude A1, 48149, Muenster, Germany. velascoa@uni-muenster.de.

Scientific Reports

|May 29, 2024

Summary

Understanding thrombus MRI characteristics improves acute ischemic stroke diagnosis. This study reveals how clot composition, particularly fibrin and iron, influences MRI T1 and T2 relaxation times, enhancing clot visualization.

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Last Updated: Jun 25, 2025

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A Magnetic Resonance Imaging Protocol for Stroke Onset Time Estimation in Permanent Cerebral Ischemia

A Magnetic Resonance Imaging Protocol for Stroke Onset Time Estimation in Permanent Cerebral Ischemia

Published on: September 16, 2017

Area of Science:

Biomedical Imaging
Neuroscience
Materials Science

Background:

Current Magnetic Resonance Imaging (MRI) visualization of thrombi in acute ischemic stroke is suboptimal.
MRI signal intensities are determined by tissue relaxation times (T1 and T2).
Understanding clot composition's effect on relaxation times can enhance MRI sequences.

Purpose of the Study:

To investigate the relationship between clot composition and MRI relaxation times (T1 and T2).
To evaluate the imaging characteristics of various clot analogs using specific MRI sequences.
To determine how clot components influence signal intensity for improved thrombus detection.

Main Methods:

Studied relaxation times and MRI characteristics of diverse clot analogs.
Analyzed three MRI sequences: T1w Turbo IR, T1w TSE SPIR, and T2w TSE DRIVE.
Compared clot imaging behavior and intensity values with normal brain tissue.

Main Results:

Histological composition strongly correlated with T1 relaxation times; iron content correlated with T2 relaxation times.
Fibrin content was identified as a primary biomarker for increased T1 relaxation times, enabling clot subgroup classification.
Clot signal intensity varied significantly with T1 and T2 relaxation times, with T2w DRIVE and T1w TSE sequences showing hyperintense thrombi.

Conclusions:

Clot composition directly impacts MRI relaxation times and signal intensities.
Specific MRI sequences (T2w DRIVE, T1w TSE) show promise for enhanced acute ischemic stroke thrombus visualization.
Findings support optimizing MRI protocols for improved thrombus detection and characterization.