JUN mediates the senescence associated secretory phenotype and immune cell recruitment to prevent prostate cancer progression
These videos have been matched automatically. Contact us if they are not relevant.
These videos have been matched automatically. Contact us if they are not relevant.
View abstract on PubMed
Summary
This summary is machine-generated.JUN acts as a tumor suppressor in prostate cancer, slowing progression by regulating senescence and inflammation genes. This finding offers new therapeutic strategies for improving patient outcomes.
Area Of Science
- Oncology
- Molecular Biology
- Immunology
Background
- Prostate cancer progression is a mutation-driven process.
- The role of activator protein-1 transcription factors, like JUN, in prostate cancer is not fully understood.
- Understanding molecular programs is crucial for identifying therapeutic targets.
Purpose Of The Study
- To analyze JUN expression in clinical prostate cancer samples.
- To investigate the functional role of JUN in prostate cancer progression using a mouse model.
- To explore the impact of JUN on the tumor microenvironment, including senescence and inflammation.
Main Methods
- Analysis of JUN expression in human prostate cancer samples.
- Functional studies in a Pten-deficient mouse model.
- Histopathological examination, transcriptomic analysis, and senescence-associated secretory phenotype assessment.
Main Results
- Elevated JUN levels in early-stage prostate cancer correlated with improved survival.
- JUN depletion in a Pten-deficient model accelerated tumor growth by impairing immune cell attraction and reducing IL-1β and STAT3 activation.
- JUN depletion reversed senescence-associated secretory phenotype and immune infiltration but did not affect cell cycle arrest.
Conclusions
- JUN functions as a tumor suppressor in prostate cancer.
- JUN decelerates prostate cancer progression via transcriptional regulation of senescence- and inflammation-associated genes.
- This research suggests novel therapeutic strategies targeting JUN-regulated pathways to improve patient outcomes.
These videos have been matched automatically. Contact us if they are not relevant.
These videos have been matched automatically. Contact us if they are not relevant.
Related Concept Videos
An inflammatory response is a localized, nonspecific immune reaction that occurs when a tissue is injured. It is characterized by redness, swelling, heat, and pain, which are commonly called the cardinal signs and symptoms of inflammation. Inflammation can sometimes result in a loss of function.
Inflammation can be triggered by various stimuli, such as impact, abrasion, chemical irritation, infections, and extreme hot or cold temperatures. These can damage cells and connective tissue fibers,...
Signaling cascades usually lack linearity. Multiple pathways interact and regulate one another, allowing cells to integrate and respond to diverse environmental stimuli.
Convergence and divergence, and cross-talk between signaling pathways
Two distinct signaling pathways can converge on a single functional unit, which may either be a single protein or a complex of proteins. The response is either functionally distinct or synergistic between the two pathways but different from the response...
Notch signaling was first discovered in Drosophila melanogaster, where it is involved in cell lineage differentiation. Notch signaling regulates the maintenance and differentiation of intestinal stem cells or ISCs by controlling the expression of atonal homolog 1 or Atoh1. Atoh1 directs cells to differentiate into secretory cells.
Direct cell-to-cell contact is needed for the activation of Notch signaling. The signal is initiated when a notch ligand binds to a receptor on an adjacent cell, also...
Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
Several cytokine receptors have tightly bound Janus kinase or JAK proteins attached at their cytosolic tail. Small signaling molecules such as cytokines, growth hormones, or prolactins bind to the cytokine receptors and initiate their dimerization. The dimerization brings the cytosolic JAKs together that trans-phosphorylate and activates each other. The activated JAKs now phosphorylate cytosolic tails of the cytokine receptors, which serve as binding sites for adaptor proteins such as SH2...
Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the...