Comparison of triglyceride glucose index and modified triglyceride glucose indices in prediction of cardiovascular diseases in middle aged and older Chinese adults
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View abstract on PubMed
Summary
This summary is machine-generated.The triglyceride and glucose (TyG) index effectively predicts cardiovascular disease risk, outperforming modified indices that combine it with obesity markers. This finding highlights TyG as a key indicator for identifying individuals at risk of cardiovascular events.
Area Of Science
- Cardiology
- Metabolic Syndrome
- Public Health
Background
- Insulin resistance is a key factor in cardiovascular disease (CVD) development.
- The triglyceride and glucose (TyG) index is a validated surrogate marker for insulin resistance.
- The combined predictive value of TyG index with obesity markers for CVD remains underexplored.
Purpose Of The Study
- To investigate the association between the TyG index and modified TyG indices (combined with obesity markers) and new-onset CVD.
- To evaluate the time-dependent predictive capacity of these indices for CVD events.
Main Methods
- Retrospective observational cohort study using data from the China Health and Retirement Longitudinal Study (CHARLS) with 7,115 participants.
- TyG index calculated as Ln [fasting triglyceride (mg/dL) × fasting glucose (mg/dL)/2].
- Modified TyG indices incorporated body mass index (BMI), waist circumference (WC), and waist-to-height ratio (WHtR). Adjusted Cox proportional hazards regression and Harrell's C-index were used for analysis.
Main Results
- Over 7 years, 2,136 participants developed CVD.
- The highest tertile of TyG index showed a significantly adjusted hazard ratio (HR) of 1.215 (95% CI: 1.088-1.356) for new-onset CVD compared to the lowest tertile.
- TyG index demonstrated higher predictive capacity (C-index) for CVD onset than modified TyG indices, including TyG-WHtR.
Conclusions
- The TyG index and TyG-WHtR are significantly associated with new-onset cardiovascular diseases.
- The TyG index alone is a superior predictor of incident cardiovascular events compared to modified TyG indices incorporating obesity markers.
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