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Relationship between preoperative high triglyceride-glucose index and myocardial injury following non-cardiac surgery in advanced-age patients: a retrospective cohort study

  • 0Department of Anesthesiology, The First Medical Center, Chinese People's Liberation Army (PLA) General Hospital, 28th Fuxing Road, Haidian District, Beijing, 100853, China.
Diabetology & Metabolic Syndrome +

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May 29, 2024

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May 29, 2024

View abstract on PubMed

Summary

This summary is machine-generated.

A high triglyceride-glucose index (TyG) in older adults undergoing non-cardiac surgery is linked to an increased risk of myocardial injury after non-cardiac surgery (MINS). This finding aids in identifying high-risk patients.

Area Of Science

  • Cardiology
  • Geriatric Medicine
  • Metabolic Syndrome

Background

  • Myocardial injury after non-cardiac surgery (MINS) is a frequent and often undetected complication in elderly patients.
  • The triglyceride-glucose index (TyG) is emerging as a marker for metabolic dysfunction and cardiovascular risk.

Purpose Of The Study

  • To investigate the association between the triglyceride-glucose index (TyG) and the incidence of myocardial injury after non-cardiac surgery (MINS).
  • To evaluate the predictive value of a high TyG index for MINS in patients aged 65 years and older.

Main Methods

  • A retrospective study of 7789 patients aged 65+ undergoing non-cardiac surgery.
  • Logistic regression and propensity score matching (PSM) were employed to analyze the relationship between TyG and MINS, adjusting for various risk factors.
  • Receiver operating characteristic (ROC) curve analysis identified an optimal TyG cut-off value of 8.57.

Main Results

  • A total of 481 patients (6.2%) developed MINS.
  • Patients with a TyG index ≥ 8.57 had a significantly higher risk of MINS compared to those with TyG < 8.57 (7.6% vs. 4.9%).
  • Multivariate analyses and PSM confirmed that a high TyG index (≥ 8.57) was an independent predictor of MINS, with adjusted odds ratios ranging from 1.35 to 1.46.

Conclusions

  • A preoperative triglyceride-glucose index (TyG) of 8.57 or higher is associated with an increased risk of myocardial injury after non-cardiac surgery in elderly patients.
  • The TyG index serves as a valuable, accessible biomarker for stratifying MINS risk in this population.

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