[A new sesquiterpene from Syringa oblata].

Area of Science:

• Natural Product Chemistry
• Pharmacology

Background:

• Syringa oblata, commonly known as lilac, is an aromatic plant with potential medicinal properties.
• Understanding its chemical constituents is crucial for exploring its therapeutic applications.

Purpose of the Study:

• To isolate and identify chemical compounds from the aromatic parts of Syringa oblata.
• To evaluate the anti-inflammatory potential of the isolated compounds.

Main Methods:

• Systematic separation and purification using silica gel column chromatography, thin-layer chromatography, and liquid chromatography.
• Structural elucidation employing UV, IR, NMR, HR-ESI-MS, X-ray diffraction, and literature data comparison.

Main Results:

• Ten compounds were identified: oblatanoid D (a novel sesquiterpene), (-)-T-muurolol, oblatanoid E-G, 14-noreudesma-3-hydroxy-3-en-2,9-dione, 1-isopropyl-2,7-dimethylnaphthalene, isocoradiol, α-calacorene, and cadin-4-en-1-β-ol.
• Nine of the identified compounds were isolated from Syringa oblata for the first time.
• Compound 1 (oblatonoid D) exhibited a significant protective effect on lipopolysaccharide (LPS)-induced inflammatory injury in RAW264.7 cells.

Conclusions:

• The study successfully identified ten compounds from Syringa oblata, including one new sesquiterpene.
• Compound 1 shows promising anti-inflammatory activity, suggesting potential therapeutic applications.