[Pathogenesis of ferroptosis on chronic kidney disease and traditional Chinese medicine intervention: a review]

Area of Science:

• Nephrology
• Cell Biology
• Integrative Medicine

Background:

• Chronic kidney disease (CKD) is a major global health concern with high incidence and costs.
• Emerging evidence links CKD pathogenesis to ferroptosis, a regulated form of cell death.
• Current research lacks comprehensive reviews on Traditional Chinese Medicine (TCM) interventions for ferroptosis in CKD.

Purpose of the Study:

• To review the relationship between ferroptosis and CKD.
• To explore the mechanisms of ferroptosis in CKD development.
• To integrate TCM theories and therapeutic strategies for intervening ferroptosis in CKD.

Main Methods:

• Systematic review of domestic and international research on ferroptosis and CKD.
• Integration of TCM concepts such as "deficiency," "stasis," "phlegm turbidity," and "toxins" related to ferroptosis.
• Summary of research on TCM active ingredients and herbal formulas targeting ferroptosis in CKD.

Main Results:

• Ferroptosis is implicated in the progression of CKD.
• TCM can modulate iron metabolism, lipid peroxidation, and antioxidant systems to inhibit ferroptosis.
• Specific TCM theories and components show promise in treating CKD by targeting ferroptosis.

Conclusions:

• Ferroptosis presents a novel perspective for understanding and treating CKD.
• TCM offers a holistic approach with potential advantages in managing CKD through ferroptosis regulation.
• This review provides new targets and directions for TCM-based therapies in CKD treatment.