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Updated: May 5, 2026

Establishment of a Severe Dry Eye Model Using Complete Dacryoadenectomy in Rabbits

Establishment of a Severe Dry Eye Model Using Complete Dacryoadenectomy in Rabbits

Published on: January 8, 2020

TRPV1 in Dry Eye Disease.

Qingqing Gou¹, Zhi Song¹, Yu Gong¹

¹Department of Ophthalmology, University-Town Hospital of Chongqing Medical University, 401331 Chongqing, China.

Frontiers in Bioscience (Landmark Edition)

|May 30, 2024

Summary

Dry eye disease involves tear film disruption and inflammation. The Transient Receptor Potential Vanilloid 1 (TRPV1) channel may play a key role in its development and could be a therapeutic target.

Area of Science:

Ophthalmology
Neuroscience
Molecular Biology

Background:

Dry eye disease (DED) is a common condition affecting the ocular surface.
DED involves tear film instability, inflammation, and nerve dysfunction.
The Transient Receptor Potential Vanilloid 1 (TRPV1) channel is implicated in DED pathogenesis.

Purpose of the Study:

To review the expression and function of TRPV1 in DED.
To outline mechanisms linking TRPV1 to DED pathophysiology.
To explore TRPV1 as a potential therapeutic target for DED.

Main Methods:

Comprehensive literature review.
Analysis of existing research on TRPV1 expression and function in ocular tissues.
Examination of studies investigating TRPV1's role in inflammatory and hyperosmotic pathways relevant to DED.

Keywords:

TRPV1 dry eye disease (DED)review

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Main Results:

TRPV1 is expressed in ocular surface tissues and cells relevant to DED.
TRPV1 activation by stimuli like hyperosmolarity and inflammatory agents contributes to DED.
Evidence suggests TRPV1 modulates inflammatory responses and sensory signaling in DED.

Conclusions:

TRPV1 is a significant factor in the initiation and progression of DED.
Targeting TRPV1 may offer a novel therapeutic strategy for managing dry eye disease.
Further research is warranted to fully elucidate TRPV1's role and therapeutic potential in DED.