Potentially functional genetic variants in interferon regulatory factor family genes are associated with colorectal cancer survival
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View abstract on PubMed
Summary
This summary is machine-generated.A specific genetic variation in the IRF6 gene (rs141112353) is linked to poorer colorectal cancer (CRC) survival. This variant impacts IRF6 gene expression and may influence tumor immunity, affecting patient outcomes.
Area Of Science
- Genetics
- Oncology
- Molecular Biology
Background
- Interferon regulatory factor (IRF) family genes are crucial in colorectal cancer (CRC) development and patient survival.
- Single nucleotide polymorphisms (SNPs) within IRF genes may influence CRC prognosis.
Purpose Of The Study
- To investigate the impact of functional SNPs in IRF genes on colorectal cancer (CRC) patient survival.
- To elucidate the functional mechanisms underlying the association between IRF6 SNPs and CRC outcomes.
Main Methods
- Multivariate Cox regression analysis for survival prediction.
- Expression quantitative trait loci (eQTL) analysis and dual luciferase assays for functional validation.
- Analysis of The Cancer Genome Atlas (TCGA) data and in vitro experiments.
Main Results
- Three linked SNPs were identified as significant survival predictors in CRC.
- The IRF6 rs141112353 T/T genotype was associated with decreased CRC survival (HR=1.60, P=6E-04).
- This SNP variant reduced IRF6 expression, potentially through altered miRNA binding, and IRF6 overexpression inhibited CRC cell proliferation and M2 macrophage polarization.
Conclusions
- The IRF6 rs141112353 variant significantly impacts CRC survival.
- This genetic variation may affect CRC prognosis by modulating IRF6 expression and influencing tumor microenvironment.
- Findings highlight the role of IRF6 genetic variants in colorectal cancer progression and patient outcomes.
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