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Updated: Jun 25, 2025

Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease
Published on: June 16, 2020
Venetoclax-associated interstitial pneumonitis
1Department of Medicine, Division of Pulmonary and Critical Care, Houston Methodist Hospital, Houston, TX, Address: 6550 Fannin St., Houston, TX, 77030, USA.
Interstitial pneumonitis, a rare lung condition, was observed in a patient treated with venetoclax for small lymphocytic lymphoma. The condition resolved after stopping venetoclax, highlighting a potential adverse effect of this BCL-2 inhibitor.
Area of Science:
- Oncology
- Pharmacology
- Pulmonology
Background:
- Venetoclax is a targeted therapy inhibiting B-cell lymphoma 2 (BCL-2), crucial for cancer cell survival.
- It is FDA-approved for treating chronic lymphocytic leukemia (CLL), small lymphocytic lymphoma (SLL), and acute myeloid leukemia (AML).
- Current literature lacks documented cases of interstitial pneumonitis associated with venetoclax therapy.
Observation:
- A 79-year-old female patient with relapsed SLL was treated with venetoclax.
- The patient subsequently developed interstitial pneumonitis, a serious lung inflammation.
- This adverse event occurred during venetoclax treatment.
Findings:
- The interstitial pneumonitis was directly associated with venetoclax administration.
- Discontinuation of venetoclax led to the complete resolution of the patient's pneumonitis.
- This case establishes a link between venetoclax and interstitial pneumonitis.
Implications:
- Clinicians should be vigilant for interstitial pneumonitis in patients receiving venetoclax.
- Early recognition and drug cessation may prevent severe pulmonary complications.
- Further research is warranted to understand the incidence and mechanisms of venetoclax-induced pneumonitis.
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