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Pediatric paraparesis: Radiological challenges in multidrug-resistant tuberculous spondylitis based on experience in
Damayanti Sekarsari1, Quinta Febryani Handoyono2, Mohamad Yanuar Amal1
1Division of Pediatric Radiology, Department of Radiology, Faculty of Medicine, University of Indonesia, Dr. Cipto Mangunkusumo General Hospital, Jl. Salemba Raya No. 4, Senen, Central Jakarta, DKI Jakarta.
Insights
Multidrug-resistant tuberculous spondylitis in children requires prompt diagnosis. Advanced radiology is essential for identifying spinal tuberculosis, guiding treatment, and preventing long-term disability, especially in developing countries.
Area of Science:
- Pediatric Radiology
- Infectious Disease Imaging
- Spinal Tuberculosis Diagnosis
Background:
- Multidrug-resistant tuberculous spondylitis poses a global health challenge, particularly in developing nations.
- Delayed diagnosis due to non-specific symptoms can lead to severe disability in children.
- Radiology is critical for early identification and effective management of spinal tuberculosis.
Observation:
- A case study of a 20-month-old malnourished child with paraparesis and a history of parental multidrug-resistant tuberculosis exposure.
- Multimodality imaging (radiography, CT, MRI) revealed extensive spinal disease, disc involvement, paravertebral abscess, and kyphotic deformity causing neurological deficits.
- The child required both anti-tuberculosis treatment and surgical intervention.
Findings:
- Radiological examinations are pivotal in diagnosing, evaluating, and guiding the timely management of multidrug-resistant tuberculous spondylitis.
- Prompt diagnosis through imaging is crucial to prevent severe complications and reduce morbidity.
- Radiology aids in assessing extensive spine involvement and neurological deficits caused by the disease.
Implications:
- This case underscores the vital role of radiological imaging in diagnosing and managing pediatric tuberculous spondylitis in resource-limited settings.
- Early and comprehensive radiological assessment, coupled with clinical collaboration, is key to preventing disability and improving outcomes.
- Socioeconomic factors significantly contribute to the burden of tuberculosis, emphasizing the need for accessible diagnostic tools.
Abstract:
Multidrug-resistant tuberculous spondylitis is a global health issue, especially in developing nations, and non-specific symptoms lead to delay in identification, treatment, and potential disability in children. Radiology plays a crucial role in diagnosing tuberculous spondylitis, which in turn might lead to effective treatment, prevention of disability and improved patient outcomes. Our case involved a 20-month-old malnourished child presented with paraparesis, revealing a history of contact with parental multidrug-resistant tuberculosis. Multimodality radiological examinations, including conventional radiography, CT, and MRI revealed extensive disease of the spine with disc involvement, large paravertebral abscess, and kyphotic deformity which produced neurological deficits, necessitating both anti-tuberculosis regimen and surgical intervention. Radiological examinations have a pivotal role in diagnosing, evaluating and guiding timely management of multidrug-resistant tuberculous spondylitis. Prompt diagnosis of the condition is crucial in order to prevent potentially severe complications, which contribute significantly to morbidity. Our case demonstrated the importance of radiology in diagnosing extensive spine involvement of the disease causing neurological deficits. Furthermore, radiology also helps in managing tuberculous spondylitis to prevent future disability in a child patient of a developing country. This case highlights the crucial significance of radiological imaging in the diagnosis and management of pediatric tuberculous spondylitis in impoverished nations. The patient's complex medical history highlights the socioeconomic factors contributing to tuberculosis burden. Early and comprehensive radiological assessment, together with collaboration between radiologists and clinicians, is vital for timely intervention and improved outcomes in pediatric tuberculous spondylitis cases to prevent the impact of this debilitating disease on children.
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