Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Other Glycolytic Pathways01:24

Other Glycolytic Pathways

1.2K
The pentose phosphate pathway (PPP) operates in parallel with glycolysis, facilitating the metabolism of both pentoses and glucose. This pathway consists of two distinct phases: the oxidative and non-oxidative phases. While it does not directly generate ATP, the intermediates formed during the process can integrate into glycolysis, contributing to cellular energy metabolism when required.Oxidative Phase: NADPH ProductionThe oxidative phase of the pentose phosphate pathway is primarily...
1.2K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

An ancient oxidase lost in vertebrates promotes extreme stress tolerance in an emerging cnidarian model for ecology, evolution and biomedicine.

The Journal of experimental biology·2026
Same author

The sugar oxidation cascade: convergent metabolic strategies in hovering vertebrate nectarivores.

The Journal of experimental biology·2026
Same author

Correction: 'Vampire bats rapidly fuel running with essential or non-essential amino acids from a blood meal' (2024), by Rossi and Welch.

Biology letters·2025
Same author

Vampire bats rapidly fuel running with essential or non-essential amino acids from a blood meal.

Biology letters·2024
Same author

Leptin Resistance Does Not Facilitate Migratory Fattening in Ruby-Throated Hummingbirds (Archilochus Colubris).

Integrative and comparative biology·2023
Same author

Genomic insights into metabolic flux in hummingbirds.

Genome research·2023
Same journal

Same species, different risks: predation shapes hormonal profiles in a breeding sea duck, the common eider.

Conservation physiology·2026
Same journal

Two years at the editor's desk: reflections on community, diversity and impact.

Conservation physiology·2026
Same journal

Thermal and immunological stress modulate the locomotor performance of female <i>Xenopus laevis</i> frogs.

Conservation physiology·2026
Same journal

The ideal candidate for the job: how epaulette sharks (<i>Hemiscyllium ocellatum</i>) have emerged as a model for climate-ready shark conservation.

Conservation physiology·2026
Same journal

A new hormonal marker for tracking rhino pregnancy.

Conservation physiology·2026
Same journal

Fatty acid profiles recorded in ocean prey and California salmonine eggs reveal maternal ocean diets linked to thiamine deficiency.

Conservation physiology·2026
See all related articles

Related Experiment Video

Updated: May 5, 2026

Empirical, Metagenomic, and Computational Techniques Illuminate the Mechanisms by which Fungicides Compromise Bee Health
08:36

Empirical, Metagenomic, and Computational Techniques Illuminate the Mechanisms by which Fungicides Compromise Bee Health

Published on: October 9, 2017

9.7K

Heat exposure limits pentose phosphate pathway activity in bumblebees.

Giulia S Rossi1,2, Alaa Elbassiouny1, Jerrica Jamison1

  • 1Department of Biological Sciences, University of Toronto, 1265 Military Trail, Scarborough, ON M1C 1A4, Canada.

Conservation Physiology
|May 30, 2024
PubMed
Summary
This summary is machine-generated.

Climate change impacts bumblebees like Bombus impatiens. Heat stress reduces pentose phosphate pathway activity, limiting antioxidant potential and potentially affecting pollination services.

Keywords:
Climate changeglucosemetabolic pathwaysoxidative stresspollinatorsthermal stress

More Related Videos

Evaluating the Effect of Environmental Chemicals on Honey Bee Development from the Individual to Colony Level
07:39

Evaluating the Effect of Environmental Chemicals on Honey Bee Development from the Individual to Colony Level

Published on: April 1, 2017

9.1K
Monitoring Colony-level Effects of Sublethal Pesticide Exposure on Honey Bees
10:35

Monitoring Colony-level Effects of Sublethal Pesticide Exposure on Honey Bees

Published on: November 15, 2017

9.1K

Related Experiment Videos

Last Updated: May 5, 2026

Empirical, Metagenomic, and Computational Techniques Illuminate the Mechanisms by which Fungicides Compromise Bee Health
08:36

Empirical, Metagenomic, and Computational Techniques Illuminate the Mechanisms by which Fungicides Compromise Bee Health

Published on: October 9, 2017

9.7K
Evaluating the Effect of Environmental Chemicals on Honey Bee Development from the Individual to Colony Level
07:39

Evaluating the Effect of Environmental Chemicals on Honey Bee Development from the Individual to Colony Level

Published on: April 1, 2017

9.1K
Monitoring Colony-level Effects of Sublethal Pesticide Exposure on Honey Bees
10:35

Monitoring Colony-level Effects of Sublethal Pesticide Exposure on Honey Bees

Published on: November 15, 2017

9.1K

Area of Science:

  • Ecology
  • Physiology
  • Climate Change Biology

Background:

  • Bumblebee populations are declining globally due to climate change, impacting essential pollination services.
  • Bombus impatiens, an economically important bumblebee species, faces threats from extreme heat events.
  • The pentose phosphate pathway (PPP) is crucial for generating antioxidant potential via nectar sugars.

Purpose of the Study:

  • To investigate the physiological mechanisms underlying Bombus impatiens susceptibility to extreme heat.
  • To test if heat exposure limits the activity of the pentose phosphate pathway (PPP).

Main Methods:

  • Tracking PPP activity in Bombus impatiens using isotopically labeled glucose at rest, during exercise, and recovery.
  • Comparing PPP activity under moderate (22°C) and high (32°C) temperature regimes.
  • Assessing oxidative damage and antioxidant potential (GSH:GSSG ratio) after heat exposure.

Main Results:

  • PPP activity was reduced in Bombus impatiens during high ATP demand (exercise) and heat exposure.
  • Bees exposed to 32°C showed a lower GSH:GSSG ratio, indicating reduced antioxidant potential.
  • Minimal oxidative damage was observed, but antioxidant capacity was compromised under heat stress.

Conclusions:

  • Acute heat stress significantly limits PPP activity and antioxidant potential in Bombus impatiens.
  • Repeated heat stress may have severe physiological consequences for this species.
  • The findings suggest potential negative implications for North American pollination services.