Interacting and joint effects of triglyceride-glucose index and hypertension on stroke risk in middle-aged and older...

Area of Science:

• Cardiovascular Disease Epidemiology
• Metabolic Syndrome Research
• Public Health

Background:

• Triglyceride-glucose (TyG) index and hypertension are known stroke risk factors.
• The TyG index is associated with hypertension.
• No prior studies have examined the interactive effects of TyG index and hypertension on stroke risk.

Purpose of the Study:

• To investigate the mediating role of hypertension in the association between the TyG index and incident stroke.
• To examine the interaction and joint effects of the TyG index and hypertension on stroke risk.
• To analyze these relationships in middle-aged and older Chinese adults.

Main Methods:

• Utilized data from the China Health and Retirement Longitudinal Study (CHARLS), a nationally representative prospective cohort.
• Included 9,145 middle-aged and older Chinese adults without baseline stroke.
• Assessed TyG index and hypertension at baseline, with stroke outcomes followed from 2011 to 2018.

Main Results:

• The TyG index was significantly associated with increased risk of hypertension (OR 1.29) and stroke (HR 1.16).
• Significant multiplicative (HR 2.34) and additive (Synergy index 4.13) interactions were found between TyG index and hypertension regarding stroke risk.
• Mediation analysis revealed that 20.0% of the TyG index-stroke association was mediated by hypertension.

Conclusions:

• A synergistic effect exists between the TyG index and hypertension in relation to stroke risk.
• Hypertension partially mediates the association between the TyG index and stroke.
• Coordinated management strategies for both TyG index and hypertension are recommended to mitigate stroke risk.