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Related Experiment Video

Updated: Jun 25, 2025

Adjustable Stiffness, External Fixator for the Rat Femur Osteotomy and Segmental Bone Defect Models
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Adjustable bone plate: from bench to operating room.

Gazi Huri1, Erdi Özdemir1, Ömer Sunkar Biçer2

  • 1Department of Orthopedics and Traumatology, Faculty of Medicine, Hacettepe University, Ankara, Turkiye.

Turkish Journal of Medical Sciences
|May 30, 2024
PubMed
Summary

A novel adjustable bone plate (ABP) successfully facilitated segmental bone transfer in a sheep model, demonstrating its potential for treating bone defects. This innovative device allows for bone lengthening and shortening post-fixation, offering a new solution for orthopedic applications.

Keywords:
Adjustable bone platebone defectsegmental bone transfertrauma

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Area of Science:

  • Orthopedic surgery
  • Biomaterials engineering
  • Regenerative medicine

Background:

  • Current bone fixation systems lack the ability to adjust bone length after initial fixation.
  • Segmental bone defects pose significant challenges in orthopedic treatment.
  • An adjustable bone plate (ABP) was developed to enable post-fixation bone length modification.

Purpose of the Study:

  • To evaluate the segmental bone transfer capability of the novel ABP.
  • To assess the ABP's efficacy in treating critical-sized segmental bone defects in an animal model.

Main Methods:

  • The study utilized an animal model with five sheep (10 tibias).
  • A 15 mm segmental bone defect was created in each tibia and treated with an ABP.
  • The ABP's pinion mechanism was adjusted daily for 15 days post-surgery.
  • Radiological and histological examinations were performed 3 months post-operatively.

Main Results:

  • Successful bone segment transfer averaging 14.6 ± 1.2 mm was achieved in all defects.
  • Radiological and histological analyses confirmed new bone formation at transfer and docking sites.
  • No complications, plate rupture, or breakage were observed during the study.

Conclusions:

  • The adjustable bone plate (ABP) demonstrates significant potential for segmental bone transfer.
  • This novel technology shows promise for future clinical applications in treating bone defects.
  • The ABP offers a unique solution for bone lengthening and shortening after fixation.