Clinical characteristics and predictors for recurrence in chronic nonbacterial osteomyelitis: a retrospective multicenter analysis
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View abstract on PubMed
Summary
This summary is machine-generated.Chronic nonbacterial osteomyelitis (CNO) in children often recurs. Vertebral and mandibular CNO, along with high ESR at diagnosis, are linked to recurrence, impacting treatment strategies.
Area Of Science
- Pediatric Rheumatology
- Pediatric Orthopedics
- Inflammatory Diseases
Background
- Chronic nonbacterial osteomyelitis (CNO) is a rare pediatric condition with unknown causes.
- It primarily affects children and adolescents, presenting diagnostic challenges and varied outcomes.
Purpose Of The Study
- To analyze clinical features, treatment outcomes, and management strategies for pediatric CNO.
- To identify key factors associated with disease recurrence in CNO patients.
Main Methods
- Retrospective, multicenter, cross-sectional study involving 87 pediatric CNO patients.
- Data collected from 8 pediatric rheumatology centers between 2010 and 2021, with a minimum 6-month follow-up.
Main Results
- The median age of patients was 12.5 years, with a median diagnostic delay of 9.9 months.
- Multifocal CNO occurred in 86.2% of cases; one-third experienced recurrence.
- Femur and tibia were most commonly affected; vertebral and clavicular involvement noted.
- Remission rates were significantly higher with biological drugs (75.0%) compared to NSAIDs (13.3%).
Conclusions
- Vertebral and mandibular CNO involvement are associated with a higher risk of recurrence.
- Elevated erythrocyte sedimentation rate (ESR) at diagnosis is a predictor of CNO recurrence.
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