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Related Concept Videos

Mechanisms of Retrovirus-induced Cancers01:51

Mechanisms of Retrovirus-induced Cancers

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Retroviruses are RNA viruses that have been shown to cause cancers in diverse species, including chickens, mice, cats, and monkeys. The RNA genomes of these viruses are first reverse-transcribed into single and then double-stranded DNA (dsDNA) copies. This dsDNA called proviral DNA then integrates into the host genome. Subsequently, the host cell transcribes the proviral DNA in concert with the chromosomal DNA. This leads to the production of viral RNA and proteins that assemble at the host...
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  5. Biomedical And Clinical Sciences
  7. Oncology And Carcinogenesis
  9. Predictive And Prognostic Markers
  11. Oral And Periodontal Manifestation Related During Human Papilloma Virus Infections: Update On Early Prognostic Factors

Oral and periodontal manifestation related during human papilloma virus infections: Update on early prognostic factors

Mariacristina Amato1, Simona Santonocito1,2, Maria Teresa Bruno1,3

  • 1Department of General Surgery and Surgical-Medical Specialties, School of Dentistry, University of Catania, AOU "Policlinico-San Marco", Via S. Sofia 78, 95124, Catania, Italy.

Heliyon
|May 30, 2024

Related Experiment Videos

RNAscope for In situ Detection of Transcriptionally Active Human Papillomavirus in Head and Neck Squamous Cell Carcinoma
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RNAscope for In situ Detection of Transcriptionally Active Human Papillomavirus in Head and Neck Squamous Cell Carcinoma

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Chromogenic In Situ Hybridization as a Tool for HPV-Related Head and Neck Cancer Diagnosis
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Chromogenic In Situ Hybridization as a Tool for HPV-Related Head and Neck Cancer Diagnosis

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Four-color Fluorescence Immunohistochemistry of T-cell Subpopulations in Archival Formalin-fixed, Paraffin-embedded Human Oropharyngeal Squamous Cell Carcinoma Samples
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Four-color Fluorescence Immunohistochemistry of T-cell Subpopulations in Archival Formalin-fixed, Paraffin-embedded Human Oropharyngeal Squamous Cell Carcinoma Samples

Published on: July 29, 2017

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View abstract on PubMed

Summary
This summary is machine-generated.

Human Papilloma Virus (HPV) infections can cause various oral lesions, with a significant risk of malignant transformation. Early detection of HPV genotypes and infection is crucial for better prognosis and preventing complications.

Area of Science:

  • Virology
  • Oncology
  • Immunology

Background:

  • Human Papilloma Virus (HPV) is a common sexually transmitted infection implicated in squamous cell carcinomas (SCC) of the cervix and head and neck.
  • HPV infections present diverse manifestations, from asymptomatic states to benign lesions and invasive carcinomas, influenced by viral-host interactions and immune evasion.
  • The oral mucosa is a frequent site for HPV tropism, yet understanding of asymptomatic infections and benign oral lesions remains limited compared to HPV's role in oral SCC.

Purpose of the Study:

  • To review current knowledge on early clinical and bio-humoral prognostic features of HPV malignant transformation risk.
  • To focus on subclinical conditions, benign oral lesions, and the link between oral and other district HPV infections.
  • To analyze the correlation between oral HPV infection and the risk of malignant transformation.
Keywords:
Human papilloma virusOral cellOral mucosaPeriodontitis

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RNAscope for In situ Detection of Transcriptionally Active Human Papillomavirus in Head and Neck Squamous Cell Carcinoma
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Chromogenic In Situ Hybridization as a Tool for HPV-Related Head and Neck Cancer Diagnosis
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Main Methods:

  • Literature review of early clinical and bio-humoral prognostic features.
  • Analysis of subclinical HPV infections and benign oral lesions.
  • Investigation of the correlation between oral and other HPV infection sites.

Main Results:

  • The primary risk associated with HPV infection is the malignant transformation of lesions.
  • HPV-driven oropharyngeal squamous cell carcinoma (OPSCC) generally has a better prognosis than non-HPV-driven OPSCC.
  • Early detection of HPV infection and specific genotypes is vital.

Conclusions:

  • Primary prevention and early detection of HPV infection and genotypes are essential for reducing malignant complications and improving patient outcomes.
  • Understanding subclinical and benign HPV oral lesions is critical for risk assessment and prognosis.
  • Further research into the early prognostic features of HPV-related oral lesions can enhance clinical management and patient survival rates.
Prognostic markers