SLE and multiple myeloma: an underlooked link? A review of case reports from the last decade
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View abstract on PubMed
Summary
This summary is machine-generated.Systemic lupus erythematosus (SLE) patients face a higher cancer risk, with a particular underlooked link to multiple myeloma (MM). This review highlights the clinical profiles and outcomes of MM in SLE patients, emphasizing the need for awareness and further research.
Area Of Science
- Rheumatology
- Oncology
- Hematology
Background
- Systemic lupus erythematosus (SLE) is a multisystem autoimmune disease.
- Emerging evidence suggests an elevated cancer risk in SLE patients.
- The association between SLE and multiple myeloma (MM) is not well-established.
Purpose Of The Study
- To synthesize findings on the relationship between SLE and MM.
- To explore the clinical profile of MM in patients with SLE.
- To identify potential associations and outcomes.
Main Methods
- A systematic review of case reports published between 2012 and 2023.
- Searches conducted on PubMed, Embase, and Google Scholar using keywords 'SLE' and 'multiple myeloma'.
- Analysis of clinical presentation, diagnosis, treatment, and outcomes from seven case reports.
Main Results
- Seven case reports were reviewed, with most participants being female.
- MM diagnosis occurred simultaneously with SLE or followed SLE by 7 months to 30 years.
- Outcomes varied, including MM improvement in two cases and death due to complications in four cases; lupus nephritis complicated two cases.
Conclusions
- The relationship between SLE and MM requires further investigation through larger studies.
- Healthcare providers should recognize the increased malignancy risk in SLE patients.
- Tailored screening strategies are recommended for SLE patients due to potential MM risk.
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