Dapagliflozin mitigates oxidative stress, inflammatory, and histopathological markers of aging in mice
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View abstract on PubMed
Summary
This summary is machine-generated.Dapagliflozin shows anti-aging benefits in mice by reducing inflammation and improving antioxidant function. This study highlights its potential to mitigate age-related physiological decline.
Area Of Science
- Gerontology and Pharmacology
- Biomedical Research on Aging
Background
- Aging is a complex biological process with significant research interest in interventions.
- Developing strategies to slow aging and improve healthspan is a key scientific goal.
Purpose Of The Study
- To evaluate the anti-aging effects of dapagliflozin (DAPA) in a D-galactose-induced aging mouse model.
- To assess DAPA's impact on inflammatory markers and antioxidant efficacy.
Main Methods
- Forty male Swiss albino mice were used, divided into control, aging model, Vitamin C, and dapagliflozin groups.
- Aging was induced using D-galactose; treatments included saline, Vitamin C, and dapagliflozin.
- Key aging biomarkers such as inflammatory mediators (TNF-α, IL-1β) and glutathione peroxidase (GSH-Px) were measured.
Main Results
- Dapagliflozin treatment significantly reduced inflammatory mediators (TNF-α, IL-1β) compared to the aging model group.
- No significant difference in inflammatory mediators or GSH-Px was observed between Vitamin C and dapagliflozin groups.
- Dapagliflozin demonstrated beneficial effects including reduced cardiomyocyte hypertrophy, improved skin vitality, and enhanced antioxidant efficacy.
Conclusions
- Dapagliflozin exhibits significant anti-aging properties in a mouse model.
- The drug effectively mitigates key aging indicators, including inflammation and oxidative stress.
- Dapagliflozin represents a potential therapeutic agent for combating age-related physiological changes.
Keywords:
AGEs, Advanced Glycation End Products CVD, Cardiovascular Disease Ca2+, Calcium Col-I, Collagen I Col-III, Collagen III DAPA, Dapagliflozin Dapagliflozin GSH-Px, Glutathione Peroxidase H&E, Hematoxylin and Eosin Stain HPF, High Power Fields IL-1β, Interleukin-1 Beta IP, Intraperitoneally MDA, Malondialdehyde ROS, Reactive Oxygen Species SD, Standard Deviation SGLT2, Sodium-Glucose Cotransporter-2 SGLT2i, Sodium-Glucose Cotransporter 2 Inhibitors TNF-α, Tumor Necrosis Factor-Alpha aging heart inflammation oxidative stress skin
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