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Updated: Jun 25, 2025

Characterization of Functionally Associated miRNAs in Glioblastoma and their Engineering into Artificial Clusters for Gene Therapy
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Research progress on function and mechanism of long non-coding RNA in glioma

Feipeng Tai1, Xueming Zhao2

  • 1First Clinical Medical College, Shanxi Medical University, Taiyuan, China. taifeipeng@163.com.

Cellular and Molecular Biology (Noisy-Le-Grand, France)
|May 30, 2024
PubMed

Insights

Long non-coding RNAs (lncRNAs) are crucial regulators in gliomas, the most common brain tumors. Understanding lncRNA mechanisms offers new diagnostic and therapeutic strategies for glioma patients.

Area of Science:

  • Neuro-oncology
  • Molecular Biology
  • Genomics

Background:

  • Gliomas represent the most frequent primary central nervous system tumors, with current treatments offering limited patient prognosis.
  • Despite therapeutic advancements, glioma patient outcomes remain suboptimal, necessitating novel diagnostic and therapeutic targets.

Purpose of the Study:

  • To systematically review and summarize the role of long non-coding RNAs (lncRNAs) in glioma development and progression.
  • To explore the potential clinical applications of lncRNAs as biomarkers for glioma diagnosis, grading, and treatment.

Main Methods:

  • A systematic literature search was conducted on the PubMed database, adhering to Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines.
  • Forty studies meeting predefined inclusion and exclusion criteria were analyzed for study design, participant demographics, and outcomes.

Main Results:

  • lncRNAs play a critical regulatory role in gliomas, influencing tumorigenesis, proliferation, invasion, migration, and angiogenesis.
  • Specific lncRNAs, including INHEG, SATB2-AS1, PSMB8-AS1, LINC01018, and SPRY4-IT1, are differentially expressed in gliomas.
  • lncRNA expression correlates with glioma grading, tumor diameter, metastasis, and patient family history.

Conclusions:

  • lncRNAs are integral to glioma biology and represent promising molecular markers for early diagnosis, prognosis assessment, and targeted therapy.
  • Further research into lncRNA mechanisms is essential for improving glioma patient outcomes and developing novel clinical strategies.

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