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Optically Actuated Soft Microrobot Family for Single-Cell Manipulation.

Gergely T Iványi1,2, Botond Nemes1, Ilona Gróf1

  • 1HUN-REN Biological Research Centre, Szeged Institute of Biophysics, Temesvári krt. 62, Szeged, 6726, Hungary.

Advanced Materials (Deerfield Beach, Fla.)
|May 30, 2024
PubMed
Summary
This summary is machine-generated.

Researchers developed novel, deformable microrobotic tools for indirect optical trapping, enabling precise single-cell manipulation without photodamage. These tools offer easier cell attachment and release, advancing cell research applications.

Keywords:
3D microfabricationdeformable microstructureselastic photopolymersoptical trapsingle‐cell manipulationsoft robotics

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Area of Science:

  • Biophysics
  • Micro-robotics
  • Cellular Manipulation

Background:

  • Precise manipulation of nonadherent single cells is crucial for detailed investigation.
  • Optical trapping offers submicrometer precision for cell positioning and femto-Newton force measurement.
  • Indirect optical trapping uses optically trapped microtools for cell manipulation, avoiding photodamage and enhancing control.

Purpose of the Study:

  • To present a novel family of cell manipulators that are deformable by optical tweezers.
  • To enable indirect optical trapping with a simpler approach, avoiding biochemical functionalization.
  • To demonstrate applications of these soft microrobotic tools in cell manipulation.

Main Methods:

  • Utilizing high-resolution 3D lithography to create cell manipulators with predefined shapes.
  • Characterizing deformations of Ormocomp manipulators under optical forces (tens of pN).
  • Employing optical tweezers to deform and control the elasticity-based microrobotic tools.

Main Results:

  • Demonstrated a novel method for indirect optical trapping using deformable microrobots.
  • Achieved cell manipulation without biochemical functionalization, allowing for timely cell release.
  • Characterized manipulator deformation under optical forces, enabling precise control.

Conclusions:

  • Soft microrobotic tools deformable by optical tweezers offer a versatile platform for single-cell manipulation.
  • This approach simplifies indirect optical trapping and expands its applicability.
  • Potential applications include cell collection, 3D imaging, and controlled cell-cell interactions.