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Observation on the Curative Effect of Different Anti-infective Treatment Regimens for Children with Acute

Yafang Zhang, Sha Sha, Wenlong Liu

    Alternative Therapies in Health and Medicine
    |May 30, 2024
    PubMed

    Insights

    Three anti-infective regimens showed similar efficacy for pediatric acute appendicitis. Cefminox + Metronidazole is the most economical choice, while Piperacillin-Tazobactam offers the lowest antibiotic intensity to reduce resistance.

    Area of Science:

    • Pediatric Surgery
    • Infectious Diseases
    • Pharmacoeconomics

    Background:

    • Acute appendicitis is a common surgical emergency in children.
    • Effective anti-infective treatment is crucial for managing appendicitis and preventing complications.
    • Evaluating different antibiotic regimens is important for optimizing patient outcomes and healthcare costs.

    Purpose of the Study:

    • To compare the efficacy of three different anti-infective treatment regimens in children with acute appendicitis.
    • To evaluate postoperative recovery, treatment effectiveness, bacterial clearance, complication rates, and pharmacoeconomic aspects.
    • To identify the most suitable and cost-effective treatment strategy.

    Main Methods:

    • Retrospective study of 90 children undergoing laparoscopic appendectomy (May 2020 - September 2022).
    • Patients were divided into three groups receiving Piperacillin-Tazobactam, Piperacillin-Tazobactam + Metronidazole, or Cefminox + Metronidazole preoperatively.
    • Comparison of clinical outcomes, microbiological data, complication rates, pharmacoeconomics, and adverse reactions.

    Main Results:

    • All three regimens demonstrated comparable effective rates (83.33% - 90.00%) with no significant differences in bacterial clearance, complication incidence, or side effects.
    • The Cefminox + Metronidazole group showed significantly lower total hospitalization, drug, and antimicrobial costs compared to the other two groups.
    • Piperacillin-Tazobactam group exhibited the lowest intensity of antibacterial drug use.

    Conclusions:

    • Cefminox + Metronidazole is a cost-effective and preferred regimen for pediatric acute appendicitis due to its economic advantages.
    • Piperacillin-Tazobactam may be considered for its lower antibiotic intensity, potentially reducing the risk of bacterial resistance.
    • All evaluated anti-infective regimens provide similar therapeutic effects for acute appendicitis in children.
    Abstract

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