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Related Experiment Video

Updated: Jun 25, 2025

Bridging the Bio-Electronic Interface with Biofabrication

Bridging the Bio-Electronic Interface with Biofabrication

Published on: June 6, 2012

Active biointegrated living electronics for managing inflammation.

Jiuyun Shi¹, Saehyun Kim¹, Pengju Li²

¹Department of Chemistry, University of Chicago, Chicago, IL 60637, USA.

Science (New York, N.Y.)

|May 30, 2024

Summary

This summary is machine-generated.

This study introduces an active biointegrated living electronics (ABLE) platform for seamless bioelectronic interfaces. The ABLE platform enables simultaneous monitoring of biogenic, biomechanical, and bioelectrical properties for disease diagnosis.

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Last Updated: Jun 25, 2025

Bridging the Bio-Electronic Interface with Biofabrication

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Published on: June 6, 2012

Bioinspired Soft Robot with Incorporated Microelectrodes

Bioinspired Soft Robot with Incorporated Microelectrodes

Published on: February 28, 2020

Fabrication and Characterization of a Conformal Skin-like Electronic System for Quantitative, Cutaneous Wound Management

Fabrication and Characterization of a Conformal Skin-like Electronic System for Quantitative, Cutaneous Wound Management

Published on: September 2, 2015

Area of Science:

Biomedical Engineering
Bioelectronics
Microbiology

Background:

Disparities between synthetic materials and living tissues challenge bioelectrical signal transduction.
Developing seamless interfaces for electronic devices and biological tissues is crucial for disease diagnosis and treatment.

Purpose of the Study:

To introduce the active biointegrated living electronics (ABLE) platform.
To enable multimodal signal transduction at the microbial-mammalian interface.
To monitor microbial-driven intervention in psoriasis.

Main Methods:

Developed a living biointerface using a bioelectronics layout and a Staphylococcus epidermidis-laden hydrogel composite.
Prepared viscoelastic hydrogels using thermally released amylose polymer chains to sustain bacterial viability.
Utilized electrophysiological recordings and wireless probing to monitor skin electrical impedance, body temperature, and humidity.

Main Results:

The ABLE platform demonstrated capabilities across biogenic, biomechanical, and bioelectrical properties.
The living hydrogel composite supported high bacterial viability.
ABLE successfully monitored microbial-driven intervention in psoriasis through various physiological parameters.

Conclusions:

The ABLE platform offers a novel approach for seamless bioelectronic interfaces.
This living biointerface facilitates multimodal signal transduction at the microbial-mammalian nexus.
ABLE shows potential for real-time monitoring of microbial-driven conditions like psoriasis.