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Acupoint Catgut Embedding Therapy for Abdominal Obesity Treatment
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Intranasal Oxytocin for Obesity.

Franziska Plessow1, Liya Kerem1,2, Marie-Louis Wronski1,3

  • 1Neuroendocrine Unit, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston.

NEJM Evidence
|May 30, 2024
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Summary
This summary is machine-generated.

Intranasal oxytocin did not lead to weight loss in adults with obesity over 8 weeks. While it reduced caloric intake in a test meal, it did not improve body composition or energy expenditure.

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Area of Science:

  • Endocrinology
  • Metabolic Disorders
  • Pharmacology

Background:

  • Preclinical studies suggest oxytocin aids weight loss by reducing food intake and increasing energy expenditure.
  • The efficacy of oxytocin in treating human obesity remains unestablished.

Purpose of the Study:

  • To investigate the effectiveness of intranasal oxytocin in treating obesity in adults.
  • To evaluate oxytocin's impact on body weight, body composition, energy expenditure, and caloric intake.

Main Methods:

  • A randomized, double-blind, placebo-controlled trial involving adults with obesity.
  • Participants received intranasal oxytocin (24 IU) or placebo four times daily for 8 weeks.
  • Primary endpoint: change in body weight; secondary endpoints: changes in body composition, resting energy expenditure, and caloric intake.

Main Results:

  • No significant difference in body weight change was observed between the oxytocin and placebo groups.
  • Oxytocin did not show beneficial effects on body composition or resting energy expenditure.
  • Oxytocin administration was associated with a reduction in caloric intake during a test meal.

Conclusions:

  • Intranasal oxytocin administered for 8 weeks did not result in significant weight reduction in adults with obesity.
  • Further research may be needed to explore oxytocin's role in appetite regulation.