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Taste-masking methods in multiparticulate dosage forms with a focus on poorly soluble drugs
Tilen Simšič1,2, Odon Planinšek1, Ana Baumgartner1
11Faculty of Pharmacy, University of Ljubljana, 1000 Ljubljana, Slovenia.
Acta Pharmaceutica (Zagreb, Croatia)
|May 30, 2024
Summary
Developing child-friendly medicines requires effective taste masking and dissolution for multiparticulate dosage forms. This review explores current techniques for taste masking and improving drug dissolution in pediatric formulations.
Area of Science:
- Pharmaceutical Technology
- Pediatric Drug Delivery
- Formulation Science
Background:
- Traditional pediatric medication methods (crushing tablets, opening capsules) lead to inconsistent dosing.
- Child-friendly dosage forms are crucial for adherence and safety in pediatric populations.
- Multiparticulate dosage forms (mini-tablets, pellets, granules) are increasingly popular for pediatric use.
Purpose of the Study:
- To review current taste-masking techniques for multiparticulate drug formulations, focusing on film coating.
- To discuss methods for evaluating taste-masking efficacy.
- To critically summarize studies addressing both taste masking and dissolution of poorly water-soluble drugs in multiparticulate systems.
Main Methods:
- Literature review of taste-masking strategies for pediatric formulations.
- Analysis of film coating techniques for taste masking.
- Evaluation of methods for assessing taste-masking effectiveness.
- Critical summary of research on multiparticulate systems combining taste masking and dissolution enhancement.
Main Results:
- Film coating is a key technique for taste masking in multiparticulate systems.
- Various methods exist to evaluate the effectiveness of taste masking.
- Simultaneously achieving good taste masking and sufficient dissolution for poorly soluble drugs presents significant challenges.
Conclusions:
- Effective taste masking and enhanced dissolution are critical for successful multiparticulate pediatric formulations.
- Further research is needed to optimize formulations that address both taste masking and dissolution challenges.
- Advancements in formulation technology are essential for improving pediatric medication adherence and outcomes.
Keywords:
evaluation methodsfilm coatingmultiparticulate dosage formspaediatricsolubility enhancementtaste maskingMore Related Videos
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