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Updated: Jul 22, 2026

The Establishment of a Lung Colonization Assay for Circulating Tumor Cell Visualization in Lung Tissues
Published on: June 16, 2018
Improving the detection limit in lung counting with a segmented HPGe detector
Henri Jutila1, Paul Greenlees1, Tiina Torvela2
1Accelerator Laboratory, Department of Physics, University of Jyväskylä, FI-40014 Jyväskylä, Finland; Helsinki Institute of Physics, University of Helsinki, P.O. Box 64, FI-00014 Helsinki, Finland.
Abstract:
A segmented High-Purity Germanium (HPGe) detector with a thin front segment together with various active and passive shield configurations was simulated with the aim of reducing the level of background events in lung counting applications. Eight different detector models were tested in a Geant4 simulation environment in a scenario where inhaled 241Am activity was deposited in the lungs of an ICRP adult reference computational phantom. In lung counting measurements, the Compton continuum in the spectrum is generated by the natural and man-made radionuclides inside the human body and the natural background radiation from the environment. The reduction in Minimum Detectable Activity (MDA) using the segmented HPGe detector combined with an active shield compared to a model with a single germanium crystal was investigated. A reduction in MDA up to 30% and 66% was obtained for internal and external sources, respectively. The results show that the detection limit and/or the measurement time in lung counting can be reduced using such a detector configuration. Furthermore, combining the segmented HPGe detector with an active shield would be particularly useful in field measurements.
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