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ADP-ribosylation, a multifaceted modification: Functions and mechanisms in aging and aging-related diseases

Wu Hao1, Zhao Jialong1, Yuan Jiuzhi1

  • 1College of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang, China.

Ageing Research Reviews
|May 30, 2024
PubMed

Insights

ADP-ribosylation, a protein modification, is crucial in aging and related diseases. Targeting this process may offer new therapeutic strategies for healthy aging and age-related conditions.

Area of Science:

  • Biochemistry and Molecular Biology
  • Gerontology
  • Cellular Biology

Background:

  • Aging is a complex biological process linked to numerous disorders, including cardiovascular diseases, stroke, neurodegenerative diseases, cancers, and lipid metabolism disorders.
  • ADP-ribosylation is a reversible post-translational modification that alters protein and nucleic acid structure and function.
  • Emerging evidence highlights the significant role of ADP-ribosylation and its associated enzymes in the aging process and age-related diseases.

Purpose of the Study:

  • To review ADP-ribosylation-associated proteins, including ADP-ribosyl transferases, ADP-ribosyl hydrolases, and ADP-ribose binding domains.
  • To summarize current knowledge on ADP-ribosylation's regulation in the pathogenesis and progression of major aging-related diseases, organism aging, and cellular senescence.
  • To explore underlying mechanisms and propose future research directions for ADP-ribosylation in aging and age-related diseases.

Main Methods:

  • Literature review and synthesis of existing research on ADP-ribosylation.
  • Analysis of ADP-ribosylation-associated proteins and their functions.
  • Examination of ADP-ribosylation's role in aging, cellular senescence, and age-related disease pathogenesis.

Main Results:

  • The review summarizes key ADP-ribosylation-associated proteins and their domains.
  • It details the regulatory roles of ADP-ribosylation in aging, senescence, and various age-related diseases.
  • Potential underlying molecular mechanisms linking ADP-ribosylation to aging are discussed.

Conclusions:

  • ADP-ribosylation is a critical molecular network implicated in aging and age-related diseases.
  • Targeting ADP-ribosylation pathways presents a promising therapeutic avenue for promoting healthy aging and treating age-related conditions.
  • Further research is needed to fully elucidate the bio-properties of ADP-ribosylation and its therapeutic potential.
Keywords:
ADP-ribosylationAging-related diseasesCellular senescencePARPs

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