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Topical insulin for refractory persistent corneal epithelial defects.

Parisa Abdi1,2, Reza Ghaffari3, Nikoo Azad4

  • 1Translational ophthalmology Research center, Farabi Eye Hospital, School of medicine, Tehran University of Medical Sciences, Tehran, Iran. paris.abdi@gmail.com.

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|May 30, 2024
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Summary

Topical insulin eye drops effectively treat persistent epithelial defects (PEDs) unresponsive to standard care. This treatment accelerates ocular surface healing, with improved outcomes in 69.6% of patients.

Keywords:
Corneal epitheliumCorneal ulcerInsulinPersistent epithelial defect

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Area of Science:

  • Ophthalmology
  • Wound Healing
  • Regenerative Medicine

Background:

  • Persistent epithelial defects (PEDs) are challenging ocular surface conditions.
  • Conventional therapies often fail, necessitating novel treatment approaches.

Purpose of the Study:

  • To clinically evaluate the efficacy of topical insulin eye drops for refractory PEDs.
  • To assess the impact of insulin eye drops on corneal re-epithelialization rates.

Main Methods:

  • Prospective, non-randomized study of 23 patients with refractory PEDs.
  • Administration of insulin eye drops (1 U/mL) four times daily.
  • Analysis of epithelial defect resolution, time to re-epithelialization, and prognostic factors.

Main Results:

  • 16 out of 23 patients (69.6%) showed improvement.
  • Significant reduction in corneal wound area observed in 75% of small defects within 20 days.
  • Improved healing rates noted in moderate and large defects over 20-50 days.

Conclusions:

  • Topical insulin is a viable therapeutic option for persistent epithelial defects.
  • Insulin eye drops accelerate ocular surface epithelium wound healing and reduce defect size.