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Related Experiment Video

Updated: Jun 25, 2025

Author Spotlight: Non-Surgical Treatment of Melasma&#8211; Microneedling with Tranexamic Acid
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Author Spotlight: Non-Surgical Treatment of Melasma– Microneedling with Tranexamic Acid

Published on: January 19, 2024

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Update on Melasma Treatments.

Ju Young Jo1, Su Ji Chae1, Hwa Jung Ryu2

  • 1Department of Dermatology, Korea University Ansan Hospital, Ansan, Korea.

Annals of Dermatology
|May 31, 2024
PubMed
Summary
This summary is machine-generated.

Melasma, a common skin hyperpigmentation, is difficult to treat due to its similarity to photoaging. Comprehensive strategies addressing both epidermal and dermal components are needed for effective melasma management.

Keywords:
MelanosisMelasmaPathologySkin agingTherapy

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Area of Science:

  • Dermatology
  • Aesthetic Medicine
  • Skin Biology

Background:

  • Melasma is a frequent facial hyperpigmentation disorder.
  • It shares characteristics with photoaged skin, complicating treatment.
  • Recurrence is common due to underlying photoaging features.

Purpose of the Study:

  • To review conventional and innovative melasma treatments.
  • To provide an overview of melasma pathogenesis.
  • To highlight the need for comprehensive therapeutic strategies.

Main Methods:

  • Literature review of existing studies on melasma.
  • Analysis of therapeutic approaches including topical, systemic, chemical peeling, and laser therapies.
  • Examination of melasma's pathological features and comparison with photoaging.

Main Results:

  • Various treatments show efficacy but recurrence is high.
  • Melasma exhibits dermal changes similar to photoaging, such as basement membrane disruption, solar elastosis, angiogenesis, and mast cell infiltration.
  • A multi-faceted approach targeting both epidermal and dermal layers is suggested.

Conclusions:

  • Melasma management requires addressing its complex pathogenesis, including photoaging components.
  • Integrated treatment strategies are essential for improving long-term outcomes.
  • Further research into innovative treatments is warranted.